betway必威登陆网址 (betway.com )学报 ›› 2021, Vol. 42 ›› Issue (6): 415-419.DOI: 10.3969/j.issn.2097-0005.2021.06.004

• 临床研究 • 上一篇    下一篇

联合治疗对老年高血压伴肥胖者的降压疗效及外周血管病防治作用

李兴超1, 王友芳2, 朱晓松3, 赵颖馨4, 李巾魁5, 相然1, 张蒙蒙1, 张金岭1, 车峰远1*   

  1. 1.山东大学附属临沂市人民医院科研科,山东 临沂 276002;
    2.山东大学附属临沂市人民医院重症医学科,山东 临沂 276002;
    3.山东大学附属临沂市人民医院感染管理部,山东 临沂 276002;
    4.betway.com 基础医学研究所,山东 济南 250062;
    5.兰山区人民医院内科,山东 临沂 276002
  • 收稿日期:2020-12-10 出版日期:2021-06-25 发布日期:2021-08-25
  • 通讯作者: 车峰远(1971—),男,主任医师,博士研究生,主要从事神经病学研究。E-mail:che1971@126.com。
  • 作者简介:李兴超(1991—),男,住院医师,硕士研究生,主要从事流行病与卫生统计学研究。E-mail:epidemiology_li@163.com。
  • 基金资助:
    国家自然科学基金(82003435);山东省自然科学基金(ZR2014HL062, ZR2020QH332);山东省医药卫生科技发展计划(2018WS400)。

Combined treatment of senile hypertension with obesity hypertension treatment and peripheral vascular disease prevention and control of action

Li Xingchao1, Wang Youfang2, Zhu Xiaosong3, Zhao Yingxin4, Li Jinkui5, Xiang Ran1, Zhang Mengmeng1, Zhang Jinling1, Che Fengyuan1*   

  1. 1. Office of Academic Research of Linyi People's Hospital, Cheeloo College of Medicine, Shandong University, Linyi 276002, China;
    2. Intensive Care Unit of Linyi People's Hospital, Cheeloo College of Medicine, Shandong University, Linyi 276002,China;
    3. Infection Management Department of Linyi People's Hospital, Cheeloo College of Medicine, Shandong University, Linyi 276002,China;
    4. Institute of Basic Medicine, Shandong Academy of Medical Sciences,Jinan 250062,China;
    5. Internal Medicine of People's Hospital of Lanshan district, Linyi 276002,China
  • Received:2020-12-10 Online:2021-06-25 Published:2021-08-25

摘要: 目的 探讨联合治疗对老年原发性高血压合并腹型肥胖者的降压疗效及外周血管病防治作用。方法 将入选的127例受试者分为联合治疗组65例(A组)和缬沙坦组62例(B组)。两组均给予缬沙坦(80 mg/d)进行降压治疗,联合治疗组在此基础上给予瑞舒伐他汀(10 mg/d)。随访6个月。结果 ①治疗后,两组间的SBP、DBP、PP、TG、TC、LDL-c、AI较治疗前明显降低(P<0.05),HDL-c、ABI明显升高(P<0.05),且联合治疗组的变化程度大于缬沙坦组(P<0.05)。②治疗时两种药物对老年肥胖合并高血压患者的SBP、DBP、PP、ABI、AI存在交互作用,F值分别为21.599、3.167、42.845、59.633、27.506,其差异均有统计学意义(P<0.05)。③分组(治疗方法)与SBP、DBP、TG、TC、ABI、AI存在正相关(r1=-0.453,r2=-0.311,r3=-0.228,r4=-0.259,r5=-0.426,r6=-0.381,P<0.05)。结论 联合治疗对老年高血压伴肥胖者降压疗效显著,能有效调节血脂水平,充分改善外周血管动脉硬化程度,预防和控制动脉硬化疾病的发生与发展。

关键词: 联合治疗, 老年, 肥胖, 原发性高血压, 外周血管病

Abstract: Objective: To observe the antihypertensive effect of combined therapy on aged patients with primary hypertension and abdominal obesity and the prevention and treatment of peripheral vascular disease. Methods: A total of 127 elderly patients were enrolled and divided into two groups, namely, the intensified therapy group (Valsartan 80 mg/d, Rosuvastatin 10 mg/d,n=65), and the valsartan treatment group (Valsartan 80 mg/d,n=62). Regular follow-up was conducted for 6 months. Results: ① After treatment,the SBP, DBP, PP, TG, TC, LDL-c and ABI of each group were significantly lower than those before (P<0.05), HDL-c and ABI were significantly higher than those before treatment (P<0.05), and the intensified therapy group was better than the valsartan group. The antihypertensive efficiency of combined antihypertensive group was higher than that of valsartan group (P<0.05).② There was interactive effect of antihypertensive and lipid lowering therapy in lowering SBP, DBP, PP, ABI and AI (P<0.05).③ Partial correlation analysis showed that there was a positive correlation between treatment method and SBP, DBP, TG, TC,ABI and AI (P<0.05). Conclusion: Combined treatment has a significant effect on hypertension and obesity in the elderly, effectively regulating blood lipid levels, fully improving the degree of peripheral vascular arteriosclerosis, and preventing and controlling the occurrence and development of arteriosclerosis diseases.

Key words: the intensified therapy, elderly, obesity, essential hypertension, peripheral vascular disease

中图分类号: