betway必威登陆网址 (betway.com )学报 ›› 2021, Vol. 42 ›› Issue (6): 436-438.DOI: 10.3969/j.issn.2097-0005.2021.06.010

• 临床研究 • 上一篇    下一篇

加味四君子汤联合三联药物治疗Hp相关胃十二指肠溃疡的疗效

李志鹏, 李伟明   

  1. 河南中医药大学第三附属医院消化内科,河南 郑州 450000
  • 收稿日期:2020-12-28 出版日期:2021-06-25 发布日期:2021-08-25
  • 作者简介:李志鹏(1985—),男,河南长葛人,主治医师,硕士,主要从事中医内科学临床工作。E-mail:haoys1104@163.com。
  • 基金资助:
    河南省中医药betway必威亚洲 专项课题(2018ZY2105)。

Effect of modified Sijunzi Decoction combined with triple drug on HP related gastroduodenal ulcer

Li Zhipeng, Li Weiming   

  1. Dept.of Gastroenterology, the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
  • Received:2020-12-28 Online:2021-06-25 Published:2021-08-25

摘要: 目的 探讨加味四君子汤联合三联药物治疗幽门螺杆菌(Hp)阳性胃十二指肠溃疡的临床疗效。方法 86例Hp相关胃十二指肠溃疡患者采用随机数字表法将其分为观察组与对照组,对照组43例采用常规三联药物疗法治疗,观察组则在三联药物基础上联合加味四君子汤治疗,比较两组溃疡治疗效果及Hp根治情况。结果 观察组治疗后总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗前两组血清IL-8、IL-10以及胃液表皮生长因子水平比较差异无统计学意义(P>0.05),治疗后观察组IL-8、IL-10水平明显低于对照组,而胃液表皮生长因子水平明显高于对照组,差异均有统计学意义(P<0.05);观察组Hp根除率明显高于对照组,并且治疗后1年内随访结果显示观察组胃十二指肠溃疡复发率明显低于对照组,差异均有统计学意义(P<0.05)。结论 在常规三联药物基础上联合加味四君子汤治疗Hp相关胃十二指肠溃疡可有效提升其治疗有效率、改善患者血清炎症状态,并对提高Hp根除率、降低治疗后溃疡复发率具有积极作用。

关键词: 加味四君子汤, 抗Hp三联药物, 胃十二指肠溃疡, Hp根除率

Abstract: Objective: To investigate the clinical efficacy of modified Sijunzi Decoction combined with triple drug in the treatment of Helicobacter pylori (HP) positive gastroduodenal ulcer. Methods: Eighty-six patients with HP related gastroduodenal ulcer were randomly divided into the observation group and the control group. Forty-three patients in the control group were treated with conventional triple drug therapy, while the observation group were treated with modified Sijunzi Decoction on the basis of triple drug therapy. Results: The total effective rate of the observation group was significantly higher than that of the control group (P < 0.05); Before treatment, there was no significant difference in the levels of serum IL-8, IL-10 and EGF in gastric juice between the two groups (P>0.05).After treatment,the levels of IL-8 and IL-10 in the observation group were significantly lower than those in the control group, while the level of EGF in gastric juice was significantly higher than that in the control group (P<0.05); The HP eradication rate of the observation group was significantly higher than that of the control group, and the follow-up results within one year after treatment showed that the recurrence rate of gastroduodenal ulcer of the observation group was significantly lower than that of the control group (P<0.05). Conclusion: Modified Sijunzi Decoction on the basis of conventional triple drugs in the treatment of HP related gastroduodenal ulcer can effectively improve the treatment efficiency, improve the serum inflammatory state of patients, and has a positive effect on improving the eradication rate of HP and reducing the recurrence rate of ulcer after treatment.

Key words: modified Sijunzi decoction, anti HP triple drug, gastroduodenal ulcer, HP eradication rate

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