betway必威登陆网址 (betway.com )学报 ›› 2021, Vol. 42 ›› Issue (6): 439-441.DOI: 10.3969/j.issn.2097-0005.2021.06.011

• 临床研究 • 上一篇    下一篇

血清及脑脊液S-100β、NSE、MBP联合slCAM-1评估病毒性脑炎儿童神经功能的价值

刘保茹1, 周江朝2   

  1. 1.河南科技大学第一附属医院神经内科,河南 洛阳 471000;
    2.河南科技大学第一附属医院神经外科,河南 洛阳 471000
  • 收稿日期:2020-12-03 出版日期:2021-06-25 发布日期:2021-08-25
  • 作者简介:刘保茹(1982—),女,河南洛阳人,主治医师,硕士,主要从事脑血管病工作。E-mail:lf2430@163.com。
  • 基金资助:
    2019 年河南省医学科技攻关计划联合共建项目(LHGJ20191243)。

The value of serum and cerebrospinal fluid S-100β,NSE,MBP combined with slCAM-1 in evaluating the neurological function of children with viral encephalitis

Liu Baoru1, Zhou Jiangchao2   

  1. 1. Dept.of Neurology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China;
    2. Dept. of Neurosurgery,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China
  • Received:2020-12-03 Online:2021-06-25 Published:2021-08-25

摘要: 目的 探究血清及脑脊液S-100β蛋白(S-100β)、神经元特异性烯醇化酶(NSE)、髓鞘碱性蛋白(MBP)联合可溶性细胞间黏附分子-l(slCAM-1)评估病毒性脑炎儿童神经功能的价值。方法 选取2018年6月—2019年12月河南科技大学第一附属医院神经内科收治的病毒性脑炎患儿130例。根据临床表现分为无障碍组(中枢神经功能无障碍,68例)和障碍组(中枢神经功能障碍,62例)。观察各组S-100β、NSE、MBP、slCAM-1水平对患儿神经功能的评估价值。结果 障碍组血清及脑脊液S-100β、NSE、MBP、slCAM-1水平高于无障碍组,差异具有统计学意义(P<0.05)。四项联合检测敏感度、特异度高于各项单项检测,差异具有统计学意义(P<0.05)。结论 血清及脑脊液S-100β、NSE、MBP联合slCAM-1与病毒性脑炎儿童神经功能密切相关。检测四项在血清及脑脊液中水平高低有利于评估患儿神经功能情况。

关键词: S-100β, NSE, MBP, slCAM-1, 病毒性脑炎, 神经功能

Abstract: Objective: To explore the value of serum and cerebrospinal fluid S-100β, NSE, MBP combined with slCAM-1 in evaluating the neurological function of children with viral encephalitis. Methods: A total of 130 children with viral encephalitis who were admitted to the Department of Neurology in our hospital from June 2018 to December 2019 were selected. According to the clinical manifestations, they were divided into the barrier-free group (without central nervous function barrier, 68 cases) and the barrier group (with central nervous system dysfunction, 62 cases). The evaluation of the values of S-100β, NSE, MBP, slCAM-1 levels in the children with neurological function in each group was made. Results: The levels of S-100β, NSE, MBP and slCAM-1 in serum and cerebrospinal fluid of the barrier group were higher than those of the barrier group (P<0.05). The sensitivity and specificity of the four combined tests were higher than those of the individual tests(P<0.05). Conclusion: Serum and cerebrospinal fluid S-100β, NSE, MBP combined with slCAM-1 are closely related to the neurological function of children with viral encephalitis.The detection of the levels of four items in serum and cerebrospinal fluid is helpful for the assessment of the neurological function of children.

Key words: S-100β, NSE, MBP, slCAM-1, viral encephalitis, nerve function

中图分类号: