Hippo信号通路及其在非小细胞肺癌中的表达和作用

摘要/Abstract

摘要：Hippo信号通路对动物器官的生长发育以及再生发挥重要的作用。有研究表明，Yes激酶相关蛋白和转录联合激活因子PDZ结合基序组成的Hippo信号通路异常表达参与了非小细胞肺癌的发生发展，并与突变型p53有协同作用；此外，其过度表达会导致肺癌治疗耐药性发生，抑制其表达可能使癌症患者获益。了解Hippo信号通路在非小细胞肺癌中的表达和作用，有望为肺癌靶向治疗提供新的方向。

关键词:癌,非小细胞肺,基因表达,Hippo信号通路,靶向治疗

Abstract:Hippo signaling pathway plays an important role in the growth and regeneration of animal organs. Studies have shown that the misexpression of Hippo signaling pathway composed of yes-associated protein and trascriptional co-activator with PDZ-binding motif is involved in the development of non-small cell lung cancer (NSCLC) and has synergistic effect with mutant p53. In addition, its overexpression leads to drug resistance in lung cancer treatment and inhibition of its expression may benefit cancer patients. The expression and role of Hippo signaling pathway in NSCLC are described in detail, which is expected to provide a new direction for targeted therapy of lung cancer.

Key words:Carcinoma, non-small-cell lung,Gene expression,Hippo signaling pathway,Targeted therapy

王昭,王迎难,倪吉祥,朱晶. Hippo信号通路及其在非小细胞肺癌中的表达和作用[J]. 国际肿瘤学杂志, 2019, 46(4): 239-242.

Wang Zhao, Wang Yingnan, Ni Jixiang, Zhu Jing. Expression and role of Hippo signaling pathway in non-small cell lung cancer[J]. Journal of International Oncology, 2019, 46(4): 239-242.

参考文献

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