国际肿瘤学杂志››2024,Vol. 51››Issue (1): 55-58.doi:10.3760/cma.j.cn371439-20230627-00007
收稿日期:
2023-06-27修回日期:
2023-08-20出版日期:
2024-01-08发布日期:
2024-01-23通讯作者:
郭贵龙 E-mail:guoguilong@sina.comGu Huayan, Zhu Teng, Guo Guilong()
Received:
2023-06-27Revised:
2023-08-20Online:
2024-01-08Published:
2024-01-23Contact:
Guo Guilong E-mail:guoguilong@sina.com摘要:
近年来研究发现,乳腺癌组织与正常乳房组织之间存在不同的乳房微生物群。乳房微生物群与乳腺癌的发生、发展有着密切关系,其作用机制包括影响雌激素水平、脂质代谢、免疫调节和炎症反应等。调整饮食、合理使用抗生素及口服益生菌等可调节乳房微生物群,是预防和治疗乳腺癌的新方向。
顾花艳, 朱腾, 郭贵龙. 乳房微生物群与乳腺癌:现状与未来[J]. 国际肿瘤学杂志, 2024, 51(1): 55-58.
Gu Huayan, Zhu Teng, Guo Guilong. Breast microbiota and breast cancer: present and future[J]. Journal of International Oncology, 2024, 51(1): 55-58.
[1] | Mikó E, Kovács T, Sebő É, et al. Microbiome-microbial metabolome-cancer cell interactions in breast cancer-familiar, but unexplored[J].Cells,2019,8(4): 293. DOI:10.3390/cells8040293. |
[2] | Dickson RP, Erb-Downward JR, Freeman CM, et al. Bacterial topography of the healthy human lower respiratory tract[J].mBio,2017,8(1): e02287-16. DOI:10.1128/mBio.02287-16. |
[3] | Nejman D, Livyatan I, Fuks G, et al. The human tumor microbiome is composed of tumor type-specific intracellular bacteria[J].Science,2020,368(6494): 973-980. DOI:10.1126/science.aay9189. pmid:32467386 |
[4] | Pushalkar S, Hundeyin M, Daley D, et al. The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression[J].Cancer Discov,2018,8(4): 403-416. DOI:10.1158/2159-8290.CD-17-1134. pmid:29567829 |
[5] | Banerjee S, Tian T, Wei Z, et al. Distinct microbial signatures associated with different breast cancer types[J].Front Microbiol,2018,9: 951. DOI:10.3389/fmicb.2018.00951. pmid:29867857 |
[6] | Uzan-Yulzari A, Morr M, Tareef-Nabwani H, et al. The intestinal microbiome, weight, and metabolic changes in women treated by adjuvant chemotherapy for breast and gynecological malignancies[J].BMC Med,2020,18(1): 281. DOI:10.1186/s12916-020-01751-2. pmid:33081767 |
[7] | Shui L, Yang X, Li J, et al. Gut microbiome as a potential factor for modulating resistance to cancer immunotherapy[J].Front Immunol,2019,10: 2989. DOI:10.3389/fimmu.2019.02989. pmid:32010123 |
[8] | Vitorino M, Alpuim Costa D, Vicente R, et al. Local breast microbiota: a "new" player on the block[J].Cancers (Basel),2022,14(15): 3811. DOI:10.3390/cancers14153811. |
[9] | Tzeng A, Sangwan N, Jia M, et al. Human breast microbiome correlates with prognostic features and immunological signatures in breast cancer[J].Genome Med,2021,13(1): 60. DOI:10.1186/s13073-021-00874-2. pmid:33863341 |
[10] | Hieken TJ, Chen J, Chen B, et al. The breast tissue microbiome, stroma, immune cells and breast cancer[J].Neoplasia,2022,27: 100786. DOI:10.1016/j.neo.2022.100786. |
[11] | Parida S, Sharma D. Microbial alterations and risk factors of breast cancer: connections and mechanistic insights[J].Cells,2020,9(5): 1091. DOI:10.3390/cells9051091. |
[12] | Fu A, Yao B, Dong T, et al. Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer[J].Cell,2022,185(8): 1356-1372.e26. DOI:10.1016/j.cell.2022.02.027. pmid:35395179 |
[13] | Klann E, Williamson JM, Tagliamonte MS, et al. Microbiota composition in bilateral healthy breast tissue and breast tumors[J].Cancer Causes Control,2020,31(11): 1027-1038. DOI:10.1007/s10552-020-01338-5. |
[14] | Smith A, Pierre JF, Makowski L, et al. Distinct microbial communities that differ by race, stage, or breast-tumor subtype in breast tissues of non-Hispanic Black and non-Hispanic White women[J].Sci Rep,2019,9(1): 11940. DOI:10.1038/s41598-019-48348-1. pmid:31420578 |
[15] | Pollet RM, D'Agostino EH, Walton WG, et al. An atlas of β-glucuronidases in the human intestinal microbiome[J].Structure,2017,25(7): 967-977.e5. DOI:10.1016/j.str.2017.05.003. pmid:28578872 |
[16] | Sellitto A, D'Agostino Y, Alexandrova E, et al. Insights into the role of estrogen receptor β in triple-negative breast cancer[J].Cancers (Basel),2020,12(6): 1477. DOI:10.3390/cancers12061477. |
[17] | Shively CA, Register TC, Appt SE, et al. Consumption of Mediterranean versus Western diet leads to distinct mammary gland microbiome populations[J].Cell Rep,2018,25(1): 47-56.e3. DOI:10.1016/j.celrep.2018.08.078. pmid:30282037 |
[18] | Soto-Pantoja DR, Gaber M, Arnone AA, et al. Diet alters entero-mammary signaling to regulate the breast microbiome and tumorigenesis[J].Cancer Res,2021,81(14): 3890-3904. DOI:10.1158/0008-5472.CAN-20-2983. pmid:34083249 |
[19] | 罗澜, 陈创, 李昕倩, 等. 细菌与乳腺癌的关系[J].国际肿瘤学杂志,2021,48(5): 292-295. DOI:10.3760/cma.j.cn371439-20200629-00056. |
[20] | Giallourou N, Urbaniak C, Puebla-Barragan S, et al. Characterizing the breast cancer lipidome and its interaction with the tissue microbiota[J].Commun Biol,2021,4(1): 1229. DOI:10.1038/s42003-021-02710-0. pmid:34707244 |
[21] | Dadsena S, Hassan DG, Holthuis JCM. Unraveling the molecular principles by which ceramides commit cells to death[J].Cell Stress,2019,3(8): 280-283. DOI:10.15698/cst2019.08.196. pmid:31440742 |
[22] | Portincasa P, Bonfrate L, Vacca M, et al. Gut microbiota and short chain fatty acids: implications in glucose homeostasis[J].Int J Mol Sci,2022,23(3): 1105. DOI:10.3390/ijms23031105. |
[23] | Schulthess J, Pandey S, Capitani M, et al. The short chain fatty acid butyrate imprints an antimicrobial program in macrophages[J].Immunity,2019,50(2): 432-445.e7. DOI:10.1016/j.immuni.2018.12.018. pmid:30683619 |
[24] | Salimi V, Shahsavari Z, Safizadeh B, et al. Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairment[J].Lipids Health Dis,2017,16(1): 208. DOI:10.1186/s12944-017-0593-4. pmid:29096636 |
[25] | Bagheri Z, Moeinzadeh L, Razmkhah M. Roles of microbiota in cancer: from tumor development to treatment[J].J Oncol,2022,2022: 3845104. DOI:10.1155/2022/3845104. |
[26] | Chen F, Yang J, Guo Y, et al. Integrating bulk and single-cell RNA sequencing data reveals the relationship between intratumor microbiome signature and host metabolic heterogeneity in breast cancer[J].Front Immunol,2023,14: 1140995. DOI:10.3389/fimmu.2023.1140995. |
[27] | Rao Malla R, Marni R, Kumari S, et al. Microbiome assisted tumor microenvironment: emerging target of breast cancer[J].Clin Breast Cancer,2022,22(3): 200-211. DOI:10.1016/j.clbc.2021.09.002. |
[28] | Liwinski T, Zheng D, Elinav E. The microbiome and cytosolic innate immune receptors[J].Immunol Rev,2020,297(1): 207-224. DOI:10.1111/imr.12901. pmid:32658330 |
[29] | Pinato DJ, Howlett S, Ottaviani D, et al. Association of prior antibiotic treatment with survival and response to immune checkpoint inhibitor therapy in patients with cancer[J].JAMA Oncol,2019,5(12): 1774-1778. DOI:10.1001/jamaoncol.2019.2785. pmid:31513236 |
[30] | Kim H, Lee JE, Hong SH, et al. The effect of antibiotics on the clinical outcomes of patients with solid cancers undergoing immune checkpoint inhibitor treatment: a retrospective study[J].BMC Cancer,2019,19(1): 1100. DOI:10.1186/s12885-019-6267-z. pmid:31718585 |
[31] | Routy B, Le Chatelier E, Derosa L, et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors[J].Science,2018,359(6371): 91-97. DOI:10.1126/science.aan3706. pmid:29097494 |
[32] | Wang H, Rong X, Zhao G, et al. The microbial metabolite trime-thylamine N-oxide promotes antitumor immunity in triple-negative breast cancer[J].Cell Metab,2022,34(4): 581-594.e8. DOI:10.1016/j.cmet.2022.02.010. pmid:35278352 |
[33] | Geller LT, Barzily-Rokni M, Danino T, et al. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine[J].Science,2017,357(6356): 1156-1160. DOI:10.1126/science.aah5043. pmid:28912244 |
[1] | 王盈, 刘楠, 郭兵.抗体药物偶联物在转移性乳腺癌治疗中的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 364-369. |
[2] | 傅旖, 马辰莺, 张露, 周菊英.生境分析在恶性肿瘤影像组学中的研究进展[J]. 国际肿瘤学杂志, 2024, 51(5): 292-297. |
[3] | 萨蔷, 徐航程, 王佳玉.乳腺癌免疫治疗研究进展[J]. 国际肿瘤学杂志, 2024, 51(4): 227-234. |
[4] | 杨智, 陆以乔, 顾花艳, 丁佳玲, 郭贵龙.肿瘤微环境介导乳腺癌靶向治疗耐药的研究进展[J]. 国际肿瘤学杂志, 2024, 51(4): 235-238. |
[5] | 陈波光, 王苏贵, 张永杰.血清胆碱酯酶与炎症标志物在ⅠA~ⅢA期乳腺癌预后中的作用[J]. 国际肿瘤学杂志, 2024, 51(2): 73-82. |
[6] | 刘筱迪, 苏剑飞, 张静娴, 卫雪芹, 贾英杰.髓源性抑制细胞在肿瘤血管生成中的研究进展[J]. 国际肿瘤学杂志, 2024, 51(1): 50-54. |
[7] | 王景, 许文婷.中性粒细胞与淋巴细胞比值、癌胚抗原联合凝血指标对直径≤1.0 cm的良恶性乳腺结节鉴别诊断价值研究[J]. 国际肿瘤学杂志, 2023, 50(9): 520-526. |
[8] | 冯诚天, 黄芙蓉, 曹世玉, 王健宇, 南丁阿比雅思, 姜永冬, 朱娟英.HER2阳性乳腺癌患者HER2表达水平与影像学特征的关系[J]. 国际肿瘤学杂志, 2023, 50(9): 527-531. |
[9] | 冯东旭, 吴炜, 高平发, 王军, 施丽娟, 陈大伟, 李文兵, 张美峰.miR-451通过调控Rho/ROCK1信号通路对乳腺癌细胞糖酵解及凋亡的影响[J]. 国际肿瘤学杂志, 2023, 50(8): 449-456. |
[10] | 王文德, 曾德.乳腺癌内分泌治疗耐药的机制研究进展[J]. 国际肿瘤学杂志, 2023, 50(6): 352-356. |
[11] | 李青珊, 谢鑫, 张楠, 刘帅.放疗联合系统治疗在乳腺癌中的应用进展[J]. 国际肿瘤学杂志, 2023, 50(6): 362-367. |
[12] | 许萌, 姜伟, 朱海涛, 曹雄锋.癌相关成纤维细胞在肿瘤放疗抵抗中的研究进展[J]. 国际肿瘤学杂志, 2023, 50(4): 227-230. |
[13] | 丁浩, 应劲涛, 付茂勇.CAR-T在食管鳞状细胞癌治疗中的研究进展[J]. 国际肿瘤学杂志, 2023, 50(4): 231-235. |
[14] | 朱军, 黄美金, 李媛, 刘泽刚, 荀欣, 陈宏.HER2低表达乳腺癌的靶向治疗研究进展[J]. 国际肿瘤学杂志, 2023, 50(4): 236-240. |
[15] | 周婷, 徐少华, 梅林.贝伐珠单抗联合卡培他滨治疗晚期乳腺癌的有效性及安全性[J]. 国际肿瘤学杂志, 2023, 50(3): 144-149. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||