国际肿瘤学杂志

国际肿瘤学杂志››2011,Vol. 38››Issue (10): 741-744.

• 综述 •上一篇下一篇

巨噬细胞游走抑制因子在肿瘤中的作用

张宏波, 刘锦

  1. 450001郑州大学基础医学院解剖学教研室
  • 出版日期:2011-10-08发布日期:2011-09-27
  • 通讯作者:张宏波，E-mail:zhanghb@zzu.edu.cn E-mail:zhanghb@zzu.edu.cn

Role of macrophage migration-inhibitory factor in cancer

ZHANG Hong-Bo, LIU Jin

  1. Department of Anatomy,College of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001,China
  • Online:2011-10-08Published:2011-09-27

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摘要：巨噬细胞游走抑制因子(MIF)是一种独特的促进肿瘤发生的细胞因子，可直接参与癌基因诱导的恶性转化并调节细胞的分裂，也可间接通过抑制肿瘤细胞凋亡、促进肿瘤侵袭及血管生成等多方面作用影响肿瘤的发生发展。针对MIF的肿瘤生物靶向治疗可能成为肿瘤治疗的新途径。

Abstract:Macrophage migration-inhibitory factor (MIF) is a cytokine which can promote tumorigenesis. MIF can promote tumorigenesis by directly inducing oncogene transformation, stimulating cell division, as well as indirectly inhibiting tumor apoptosis, promoting its invasiveness and angiogenesis. MIF-targeted biological therapy may become a new therapeutic strategy for malignant tumor.