国际肿瘤学杂志

国际肿瘤学杂志››2011,Vol. 38››Issue (10): 783-786.

• 综述 •上一篇下一篇

黑色素瘤抗原A家族与肝细胞癌

张永俊, 张文敏

  1. 350004福州，福建医科大学基础医学院病理学系福建医科大学肿瘤研究室
  • 出版日期:2011-10-08发布日期:2011-09-27

Melanoma antigen A and hepatocellular carcinoma

ZHANG Yong-Jun, ZHANG Wen-Min

  1. Departmengt of Pathology,Cancer Institute,Fujian Medical University,Fuzhou 350004,China
  • Online:2011-10-08Published:2011-09-27

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摘要：黑色素瘤抗原A(MAGE-A)是一组肿瘤相关性抗原，主要表达于以黑色素瘤为主的多种恶性肿瘤组织中。肝细胞癌(HCC)是发生于肝脏的上皮性恶性肿瘤，患病率高，寻找有效的诊断和治疗方法成为极其迫切的任务。目前已证实MAGE-A基因在HCC组织中高表达，对HCC诊治及预后判断具有重要意义。

Abstract:Melanoma antigen A is a kind of tumor-associated antigen, which expresses in various types of hunman malignant tumor tissues especially in melanoma. Hepatocellular carcinoma (HCC) is a kind of malignant epithelialtumor with high incidence which occurs in liver.Searching foreffective diagnosis and treatment methods of it become a pressing task. It is confirmed that MAGE-A gene is highly expressed in HCC tissues which has great significance to the diagnosis, treatment and prognosis for HCC.