国际肿瘤学杂志

国际肿瘤学杂志››2011,Vol. 38››Issue (11): 806-808.

• 综述 •上一篇下一篇

微RNA对肿瘤干细胞自我更新的影响机制研究

马晓玲, 姜桦, 陈彤

  1. 200011复旦大学附属妇产科医院妇科(马晓玲、姜桦)；复旦大学附属华山医院血液科（陈彤）
  • 出版日期:2011-11-08发布日期:2011-11-03
  • 基金资助:

    上海市自然科学基金项目(09ZR1404900)；上海市科委引导项目(09411967600)

Relationship between MicroRNA and the self-renewal of cancer stem cells

MA Xiao-Ling, JIANG Hua, CHEN Tong

  1. 姜桦,E-mail:jianghua@fudan.edu.cn
  • Online:2011-11-08Published:2011-11-03

PDF

2009

摘要：肿瘤干细胞(CSC)的自我更新与肿瘤的形成、复发以及耐药有关。微RNA能够调控细胞周期，影响细胞命运。目前的研究已发现微RNA可通过直接调节相关的基因靶点作用于肿瘤干细胞的自我更新，同时可能通过影响wnt、notch、Hedgehog等信号传导途径参与调节肿瘤干细胞自我更新能力。

Abstract:Cancer stem cells (CSC) are related to the progression, recurrence and drug-resistance of tumor. MicroRNAs have been reported to correlate to the self-renewal of cancer cells. They can regulate cell cycle and thus interfere with the cell fate. Recent publications have clarified that microRNA can effect on cancer stem cells’ self-renewal either by regulate targeted genes directly, or through wnt, notch and Hedgehog pathways.