国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (2): 99-101.

• 综述 •上一篇下一篇

乳腺癌扩增基因1与肿瘤

吴晓, 洪超群, 吴名耀

  1. 515041汕头大学医学院附属肿瘤医院肿瘤病理科(吴晓、洪超群)，汕头大学医学院病理教研室（吴名耀）
  • 出版日期:2012-02-08发布日期:2012-01-18
  • 通讯作者:吴名耀，E-mail，mywu@stu.edu.cn E-mail:mywu@stu.edu.cn
  • 基金资助:

    广东省科技计划基金资助项目（2009B030801317）

Amplified in breast cancer 1 in tumorigenesis

WU Xiao, HONG Chao-Qun, WU Ming-Yao

  1. Department ofPathology ,Cancer Hospital of Shantou University Medical College,Shantou 515041,China
  • Online:2012-02-08Published:2012-01-18
  • Contact:Corresponding author: WU Ming-yao, E-mail: mywu@stu.edu.cn E-mail:mywu@stu.edu.cn

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摘要：AIB1通过与核受体结合从而在基因表达调控过程中发挥重要作用。大量研究表明，AIB1在乳腺癌、结肠癌、胃癌、食管癌、肺癌等多种肿瘤中均呈过表达。对AIB1在多种肿瘤的发病机制以及预后中作用的研究，将有助于重新了解肿瘤癌变的过程。AIB1可能成为新的预后指标及治疗靶点。

Abstract:Amplified in breast cancer 1 (AIB1) plays an important role in the process of gene expression and regulation by combining with nuclear receptor. Aberrant expression of AIB1 has been detected in different types of caners, such as breast cancer, colorectal carcinoma, gastric carcinoma, esophageal carcinoma, lung cancer, etc. The study of the potential role of AIB1 in the pathogenesis and prognosis will improve our general acknowledge of carcinogenesis. AIB1 may become a new prognostic marker as well as a new therapeutic target.