国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (5): 330-333.

• 综述 •上一篇下一篇

miR-221和miR-222在肿瘤中的研究进展

董令仪；张辉；叶颖江

  1. 北京大学人民医院胃肠外科
  • 出版日期:2012-05-08发布日期:2012-05-02
  • 通讯作者:叶颖江，E-mail：yjye101@yahoo.com.cn E-mail:yjye101@yahoo.com.cn
  • 基金资助:

    北京市自然科学基金资助项目（7112136）

Advances of miR-221/222 in tumors

DONG Ling-yi, ZHANG Hui, YE Ying-jiang

  1. Department of Gastrointestinal Surgery, Peking University People's Hospital, Beijing 100044, China
  • Online:2012-05-08Published:2012-05-02
  • Contact:YE Ying-jiang, E-mail：yjye101@yahoo.com.cn E-mail:yjye101@yahoo.com.cn

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摘要：由于微小RNA(miRNA)在肿瘤中发挥重要调控作用及其自身特点，使其可能成为基因靶向治疗的有效工具。因此，人们致力于寻找调节关键癌基因或抑癌基因的miRNA。研究发现miR-221及miR-222在多种人类肿瘤中不仅表达异常，而且在不同类型的肿瘤中也发挥着不同的癌基因或抑癌基因样作用，通过调控miR-221和miR-222的表达可能成为肿瘤治疗的有效方法。

Abstract:Because of the characteristics of microRNAs (miRNAs) and their important regulative roles in human tumor diseases, they may be novel approaches for gene target therapy. Most studies focus on finding critical regulator miRNAs of oncogenes or tumor suppressor genes. Recent researches show that the expression of miR-221 and miR-222 are abnormal, and they play different roles in different types of human tumors. The regulation of miR-221 and miR-222 may be a novel effective therapy for tumor.