国际肿瘤学杂志››2013,Vol. 40››Issue (6): 416-418.

• 综述 •上一篇下一篇

缺氧诱导因子促进肿瘤血管生成的研究

隋文文, 张维东

  1. 250062济南,betway.com 基础医学研究所实验病理研究室;济南大学betway.com 医学与生命科学学院
  • 出版日期:2013-06-08发布日期:2013-05-24
  • 通讯作者:张维东,E-mail:zhangweidongkui@163.com E-mail:zhangweidongkui@163.com
  • 基金资助:

    国家自然科学基金(81073102

Research of hypoxia-inducible factor contribute to tumor angiogenesis

SUI Wen-Wen, ZHANG Wei-Dong

  1. Department of Pathology, Institute of Basic Medicine, Shandong Academy of Medical Sciences; School of Medicine and Life Sciences, University of Jinan- Shandong Academy of Medical Sciences, Jinan 250062, China
  • Online:2013-06-08Published:2013-05-24
  • Contact:ZHANG Wei-dong E-mail:zhangweidongkui@163.com

摘要:缺氧诱导因子(HIF)是缺氧应答中起重要作用的转录因子,在实体瘤中呈普遍高表达,与肿瘤血管生成密切相关。其主要通过上调血管内皮生长因子(VEGF)基因的激活启动相关的血管生成,促进肿瘤的生长、侵袭及转移。随着HIF调控肿瘤血管生成机制的研究深入,HIF有望成为抗肿瘤血管生成治疗的重要靶点。

关键词:缺氧诱导因子,血管内皮生长因子类,新生血管化,病理性

Abstract:Department of Pathology, Institute of Basic Medicine, Shandong Academy of Medical Sciences; School of Medicine and Life Sciences, University of Jinan- Shandong Academy of Medical Sciences, Jinan 250062, China

Key words:Hypoxia-inducible factor,Vascular endothelial growth factors,Neovascularization, pathologic