国际肿瘤学杂志

国际肿瘤学杂志››2013,Vol. 40››Issue (10): 758-761.

• 综述 •上一篇下一篇

肺癌动物模型

刘军, 靳晶, 崔淑香

  1. 250062济南，betway.com 药物研究所药理室济南大学betway.com 医学与生命科学学院 山东省罕少见病重点实验室（刘军、崔淑香）；山东大学药学院（靳晶）
  • 出版日期:2013-10-08发布日期:2013-09-23
  • 通讯作者:崔淑香，E-mail: sxccui@sina.com E-mail:sxccui@sina.com
  • 基金资助:

    国家自然科学基金（81072665）

Animal models of lung cancer

LIU Jun, JIN Jing, CUI Shu-Xiang

  1. Department of Pharmacology, Institute of Materia Medica, Shandong Academy of Medical Sciences; School of Medicine and Life Sciences, University of Ji’nan-Shandong Academy of Medical Sciences; Key Laboratory for Rare Disease of Shandong Province, Ji’nan 250062,[1]China
  • Online:2013-10-08Published:2013-09-23
  • Contact:CUI Shu-xiang, E-mail: sxccui@sina.com E-mail:sxccui@sina.com

PDF

2209

摘要：研究制定合理有效的肺癌治疗措施，需要建立合适的动物模型。自发或由致癌物诱发的肺癌模型所需成瘤时间长，成瘤率不能保证；移植瘤模型成瘤率稳定且所需成瘤时间较短被实验室广泛运用；基于基因技术的转基因小鼠肺肿瘤模型，不仅有利于肺癌病理过程的理解，而且能提供理想的靶向治疗实验的临床前模型，将成为肺癌动物模型的重要发展方向。

关键词:肺肿瘤,模型,动物

Abstract:In order to make a rational andeffectivecure measure for lung cancer, we need to establishsuitableanimal model. Spontaneous or induced model needs long time to form tumor and therateis not steady. Xenograft mouse model is widely used inlaboratoriesbecause of its steadytumorformationrateand less time in oncogenesis. Engineered mouse model whichis based ongenetic technologynot only helps us tounderstandpathological processof lung cancer, but also can provide an ideal preclinical model oftargetedtherapyexperiment, and it will be theimportantdevelopment directionof lung canceranimal model.

Key words:Lung neoplasms,Models, animal