国际肿瘤学杂志››2014,Vol. 41››Issue (3): 206-208.doi:10.3760/cma.j.issn.1673-422X.2014.03.014

• 综述 •上一篇下一篇

D4-鸟苷酸解离抑制因子在肺癌发病机制中的研究进展

罗新岳, 胡瑞成, 戴爱国

  1. 410016 长沙,南华大学附属省马王堆医院
  • 出版日期:2014-03-08发布日期:2014-03-17
  • 通讯作者:胡瑞成,E-mail: huruicheng@hotmail.com E-mail:huruicheng@hotmail.com
  • 基金资助:
    国家自然科学基金(81070035)

Research progress of D4-GDI in the pathogenesis of lung cancer

LUO Xin-Yue, HU Rui-Cheng, DAI Ai-Guo

  1. University of South China Affiliated Provincial Mawangdui Hospital, Changsha 410016, China
  • Online:2014-03-08Published:2014-03-17
  • Contact:Hu Ruicheng, E-mail: huruicheng@hotmail.com E-mail:huruicheng@hotmail.com

摘要:D4-鸟苷酸解离抑制因子(GDI)是Rho GDP解离抑制因子家族的主要成员之一,抑制Rho蛋白与GDP解离,参与细胞的收缩、黏附、迁移、增殖、凋亡等多种生物学行为。目前已证实D4-GDI参与了肺癌等多种呼吸系统疾病的病理生理过程,干预D4-GDI的表达能够改善这些疾病的病理改变与预后。

关键词:细胞凋亡,炎症,信号通路,肺肿瘤,D4-GDI

Abstract:As one of the main members of the Rho GDI dissociation inhibitory factors, D4-GDI inhibits the dissociation of Rho protein and GDP, which is also involved in a wide range of celluar functions, such as cell contraction, adhesion, migration, proliferation and apoptosis. Recently, accumulating evidence has been suggested that D4-GDI is involved in the pathogenesis of several pulmonary diseases, such as lung cancer. Intervention of D4-GDI expression may improve the pathological changes and prognosis of these diseases.

Key words:Apoptosis,Inflammation,Signaling pathway,Lung neoplasms,D4-GDI