小细胞肺癌的靶向治疗

国际肿瘤学杂志››2015,Vol. 42››Issue (6): 452-454.doi:10.3760/cma.j.issn.1673,422X.2015.06.014

王文娴,张沂平

310022杭州，浙江中医药大学附属浙江省肿瘤医院化疗中心

收稿日期:2014-10-31出版日期:2015-06-08发布日期:2015-05-31
通讯作者:张沂平，Email: zyp@medmail.com.cn E-mail:张沂平，Email: zyp@medmail.com.cn
基金资助:

卫生部医药卫生科技发展研究中心课题（W2012FZ134）；浙江省自然科学基金（LY13H160024）

Targeted therapy for small cell lung cancer

Wang Wenxian, Zhang Yiping

Department of Chemotherapy, Zhejiang Cancer Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310022, China

Received:2014-10-31Online:2015-06-08Published:2015-05-31
Contact:Zhang Yiping E-mail:张沂平，Email: zyp@medmail.com.cn

摘要/Abstract

摘要：小细胞肺癌（SCLC）靶向治疗药物包括血管生成抑制剂、酪氨酸激酶抑制剂和信号通路抑制剂等。研究表明血管生成抑制剂如贝伐珠单抗疗效并不显著；酪氨酸激酶抑制剂如舒尼替尼等可能更适合单药治疗；信号通路抑制剂如Amuvatinib、LDE225等正在进行Ⅰ、Ⅱ期临床试验。目前认为SCLC对于靶向治疗不敏感，或更具有选择性和针对性，有待于进一步研究。

王文娴,张沂平. 小细胞肺癌的靶向治疗[J]. 国际肿瘤学杂志, 2015, 42(6): 452-454.

Wang Wenxian, Zhang Yiping. Targeted therapy for small cell lung cancer[J]. Journal of International Oncology, 2015, 42(6): 452-454.

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