转录因子AP-2在泌尿生殖系统肿瘤中的研究进展

国际肿瘤学杂志››2015,Vol. 42››Issue (7): 548-550.doi:10.3760/cma.j.issn.1673-422X.2015.07.020

转录因子AP-2在泌尿生殖系统肿瘤中的研究进展

谢宇，范刚，张健

410081长沙，湖南师范大学生命科学学院蛋白质化学与发育生物学教育部重点实验室（谢宇、张健）；中南大学湘雅医学院附属肿瘤医院暨湖南省肿瘤医院泌尿外科（谢宇、范刚）

出版日期:2015-07-08发布日期:2015-05-26
通讯作者:张健 E-mail:zhangjian@hunnu.edu.cn
基金资助:

中南大学中央高校基本科研业务费专项资金（2177/72150050625)

Research progress of transcription factor AP-2 in urogenital cancer

Xie Yu, Fan Gang, Zhang Jian

Key Laboratory of Protein Chemistry and Developmental Biology of State Education Ministry of China, College of Life Sciences, Hunan Normal University; Department of Urology, Hunan Provincial Tumor Hospital, Affiliated Cancer Hospital of Xiangya Medical College, Central South University, Changsha 410081, China

Online:2015-07-08Published:2015-05-26
Contact:Zhang Jian E-mail:zhangjian@hunnu.edu.cn

摘要/Abstract

摘要：转录因子激活蛋白2（AP2）在肿瘤细胞的增殖、分化、癌变及化疗耐药方面扮演着重要角色。AP2在不同泌尿生殖系统肿瘤组织中分别呈现出抑癌或促癌的双向调控效应。研究AP2在泌尿生殖系统肿瘤中的作用及作用机制可为相关肿瘤的诊治提供新的思路和方向。

谢宇，范刚，张健. 转录因子AP-2在泌尿生殖系统肿瘤中的研究进展[J]. 国际肿瘤学杂志, 2015, 42(7): 548-550.

Xie Yu, Fan Gang, Zhang Jian. Research progress of transcription factor AP-2 in urogenital cancer[J]. Journal of International Oncology, 2015, 42(7): 548-550.

［1］ Zarelli VE, Dawid IB. Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP2［J］. Proc Natl Acad Sci USA, 2013, 110(8): 2870-2875. ［2］ Praetorius C, Grill C, Stacey SN, et al. A polymorphism in IRF4 affects human pigmentation through a tyrosinasedependent MITF/TFAP2A pathway［J］. Cell, 2013, 155(5): 1022-1033. ［3］ Wenke AK, Bosserhoff AK. Roles of AP2 transcription factors in the regulation of cartilage and skeletal development［J］. FEBS J, 2010, 277(4): 894-902. ［4］王义军, 徐甜, 胡翔, 等. 转录因子AP2β与 SLP2的蛋白相互作用［J］. 生命betway必威亚洲 , 2010, 14(1): 16-20. ［5］ Handwerger S. New insights into the regulation of human cytotrophoblast cell differentiation［J］. Mol Cell Endocrinol, 2010, 323(1): 94-104. ［6］ Zarelli VE, Dawid IB. Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP2［J］. Proc Natl Acad Sci USA, 2013, 110(8): 2870-2875. ［7］ Carrière C, Mirocha S, Deharvengt S, et al. Aberrant expressions of AP2α splice variants in pancreatic cancer［J］. Pancreas, 2011, 40(5): 695-700. ［8］ Chen L, Zhu H, Pan Y, et al. Ascorbic acid uptaken by sodiumdependent vitamin C transporter 2 induces βhCG expression through Sp1 and TFAP2A transcription factors in human choriocarcinoma cells［J］. J Clin Endocrinol Metab, 2012, 97(9): E1667-1676. ［9］ Nakaya Y, Shimode S, Kobayashi T, et al. Binding of transcription factor activating protein 2 γ on the 5′proximal promoter region of human porcine endogenous retrovirus subgroup A receptor 2/GPR172B［J］. Xenotransplantation, 2012, 19(3): 177-185. ［10］ Zhang X, Leung YK, Ho SM. AP2 regulates the transcription of estrogen receptor (ER)β by acting through a methylation hotspot of the 0N promoter in prostate cancer cells［J］. Oncogene, 2007, 26(52): 7346-7354. ［11］ Qin HR, Iliopoulos D, Nakamura T, et al. Wwox suppresses prostate cancer cell growth through modulation of ErbB2mediated androgen receptor signaling［J］. Mol Cancer Res, 2007, 5(9): 957-965. ［12］杨直, 曲利娟, 武一曼, 等. DRnm23在大肠癌组织中的蛋白表达及意义［J］. 世界华人消化杂志, 2010, 18(15): 1563-1568. ［13］童英, 成元华, 文安智. 精原细胞瘤中M2A、AP2γ、0CT3/4、PLAP和CD117的表达及其意义［J］. 实用医学杂志, 2011, 27(8): 1338-1340. ［14］赵晓蒙, 王成, 李晓峰, 等. 转录因子OCT4对靶基因AP2γ表达调控的研究［J］. 生物化学与生物物理进展, 2013, 40(1): 43-49. ［15］ Looijenga LH. Spermatocytic seminoma: toward further understanding of pathogenesis［J］. J Pathol, 2011, 224(4): 431-433. ［16］ Nielsen JE, Kristensen DM, Almstrup K, et al. A novel double staining strategy for improved detection of testicular carcinoma in situ cells in human semen samples［J］. Andrologia, 2012, 44(2): 78-85. ［17］ Wu Y, Xiao Y, Ding X, et al. A miR200b/200c/429binding site polymorphism in the 3′ untranslated region of the AP2α gene is associated with cisplatin resistance［J］. PLoS One, 2011, 6(12): e29043. ［18］ Jonckheere N, Fauquette V, Stechly L, et al. Tumour growth and resistance to gemcitabine of pancreatic cancer cells are decreased by AP2α overexpression［J］. Br J Cancer, 2009, 101(4): 637-644. ［19］吕林, 陈自宪, 罗绪刚. 金属硫蛋白在动物体内的功能及其基因表达调控［J］. 微量元素与健康研究, 2010, 27(4): 58-61. ［20］ Thewes V, Orso F, Jger R, et al. Interference with activator protein2 transcription factors leads to induction of apoptosis and an increase in chemo and radiationsensitivity in breast cancer cells［J］. BMC Cancer, 2010, 10: 192.