长非编码RNA与其他表观遗传机制的相互调控在肿瘤中的作用机制

摘要/Abstract

摘要：长非编码RNA（lncRNA）的异常表达与多种肿瘤相关。最新研究发现，lncRNA一方面可以通过多种途径调控其他表观遗传方式，包括DNA甲基化、组蛋白修饰、miRNA、染色质重构；另一方面，其他表观遗传形式也能够调控lncRNA的表达，两者的相互调控对恶性肿瘤的发生和发展起着重要作用。对其中机制的深入研究有助于更加清晰地阐明肿瘤的发生机制，并为以lncRNA为靶点的肿瘤治疗提供理论基础。

党旖旎, 张国新. 长非编码RNA与其他表观遗传机制的相互调控在肿瘤中的作用机制[J]. 国际肿瘤学杂志, 2015, 42(8): 671-.

DANG Yi-Ni, ZHANG Guo-Xin. Functional mechanism of the mutual regulation between long noncoding RNAs and other epigenetic mechanisms in cancer[J]. Journal of International Oncology, 2015, 42(8): 671-.

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