国际肿瘤学杂志››2015,Vol. 42››Issue (8): 689-.doi:10.3760/cma.j.issn.1673422X.2015.09.013
刘娟, 马代远
出版日期:
2015-09-08发布日期:
2015-08-12LIU Juan, MA Dai-Yuan
Online:
2015-09-08Published:
2015-08-12摘要:放疗是头颈部肿瘤最主要的治疗手段,但会导致相邻组织的损害,其中放射性口干症是最常见的并发症。放疗所致腮腺损伤机制目前尚不清楚。腮腺功能的检测包括测量唾液流量与唾液流率、腮腺单光子发射计算机断层成像术(SPECT)、CT及磁共振成像(MRI)等。如何保护腮腺成为近年来研究的热点。目前保护腮腺的方法主要有放疗方式的选择、放疗计划的优化、药物、干细胞移植、基因转导。
刘娟, 马代远. 腮腺保护在头颈部肿瘤放疗中的研究进展[J]. 国际肿瘤学杂志, 2015, 42(8): 689-.
LIU Juan, MA Dai-Yuan. Research progress in radiotherapy for head and neck tumors in parotid gland protection[J]. Journal of International Oncology, 2015, 42(8): 689-.
[1] Wang X, Lu J, Xiong X, et al. Anatomic and dosimetric changes during the treatment course of intensitymodulated radiotherapy for locally advanced nasopharyngeal carcinoma[J]. Med Dosim, 2010, 35(2):151157. [2] Randall K, Stevens J, Yepes JF, et al. Analysis of factors influencing the development of xerostomia during intensitymodulated radiotherapy[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2013, 115(6):772729. [3] Coppes RP, Stokman MA. Stem cells and the repair of radiationinduced salivary gland damage[J]. Oral Dis, 2011, 17(2):143153. [4] Wang RS, Zhang TT, Xu ZH, et al. Injury in minipig parotid glands following fractionated exposure to 30 Gy of ionizing radiation[J]. Otolaryngol Head Neck Surg, 2014, 151(1):100106. [5] Kang JY, Jang SJ, Lee WW, et al. Evaluation of salivary gland dysfunction using salivary gland scintigraphy in sjogren′s syndrome patients and in thyroid cancer patients after radioactive iodine therapy[J]. Nucl Med Mol Imaging, 2011, 45(3):161168. [6] Mojsak MN, Rogowski F. Application scintigraphy in evaluation of salivary gland function[J]. Pol Merkur Lekarski, 2010, 28(165):214219. [7] Motallebnejad M, Abedi SM, Seyedmajidi M, et al. Evaluation of protective effect of propolis on parotid salivary glands in gammairradiated rats[J]. Contemp Dent Pract, 2014, 15(1): 811. [8] Obinata K, Nakamura M, Carrozzo M, et al. Changes in parotid gland morphology and function in patients treated with intensitymodulated radiotherapy for nasopharyngeal and oropharyngeal tumors[J]. Oral Radiol, 2014, 30: 135141. [9] Kato H, Kanematsu M, Toida M, et al. Salivary gland function evaluated by diffusionweighted MR imaging with gustatory stimulation: preliminary results[J]. J Magn Reson Imaging, 2011, 34(4):904909. [10] Zhang Y, Ou D, Gu Y, et al. Diffusionweighted MR imaging of salivary glands with gustatory stimulation: comparison before and after radiotherapy[J]. Acta Radiol, 2013, 54(8): 928933. [11] Moretto F, Rampino M, Munoz F, et al. Conventional 2D (2DRT) and 3D conformal radiotherapy (3DCRT) versus intensitymodulated radiotherapy (IMRT) for nasopharyngeal cancer treatment[J]. Radiol Med, 2014, 119(8): 634641. [12] Kouloulias V, Thalassinou S, Platoni K, et al. The treatment outcome and radiationinduced toxicity for patients with head and neck carcinoma in the IMRT era: a systematic review with dosimetric and clinical parameters[J]. Biomed Res Int, 2013, 2013:401261. [13] Phua Chee Ee V, Tan BS, Tan AL, et al. Dose planning study of target volume coverage with intensitymodulated radiotherapy for nasopharyngeal carcinoma: Penang General Hospital experience[J]. Asian Pac J Cancer Prev, 2013, 14(4): 22432248. [14] Tribius S, Bergelt C. Intensitymodulated radiotherapy versus conventional and 3D conformal radiotherapy in patients with head and neck cancer: is there a worthwhile quality of life gain?[J]. Cancer Treat Rev, 2011, 37(7):511519. [15] Chen J, Mok E, Wang L, et al. Volumetricmodulated arc radiotherapy for skullbase and nonskullbase head and neck cancer: a treatment planning comparison with fixed Beam IMRT [J]. Technol Cancer Res Treat, 2013, 12(1): 1118. [16] Nithya L, Raj NA, Kumar A, et al. Comparative analysis of volumetricmodulated arc therapy and intensitymodulated radiotherapy for base of tongue cancer[J]. Med Phys, 2014, 39(2):121126. [17] Chen J, Mok E, Wang L, et al. Volumetricmodulated arc radiotherapy for skullbase and nonskullbase head and neck cancer: a treatment planning comparison with fixed Beam IMRT [J]. Technol Cancer Res Treat, 2013, 12(1): 1118. [18] Chen C, Fei Z, Chen L, et al. Will weight loss cause significant dosimetric changes of target volumes and organs at risk in nasopharyngeal carcinoma treated with intensitymodulated radiation therapy? [J]. Med Dosim, 2014, 39(1): 3437. [19] Beltran M, Ramos M, Rovira JJ, et al. Dose variations in tumor volumes and organs at risk during IMRT for headandneck cancer[J]. Appl Clin Med Phys, 2012, 13(6): 3723. [20] Fiorentino A, Cozzolino M, Caivano R, et al. Head and neck intensity modulated radiotherapy parotid glands: time of replanning[J]. Radiol Med, 2014, 119(3): 201207. [21] 魏双, 郝俊芳, 杨新华, 等. 鼻咽癌调强放疗每周腮腺动态变化的临床分析[J]. 中国癌症杂志, 2013, 23(3): 211217. [22] Zhou Y, Chen HI, Lin AL, et al. Early gene expression in salivary gland after isoproterenol treatment[J]. J Cell Biochem, 2015, 116(3):431437. [23] Spiegelberg L, Djasim UM, van Neck JW, et al. The effects of heparan sulphate mimetic RGTAOTR4120 on irradiated murine salivary glands[J]. Oral Pathol Med, 2012, 41(6): 477483. [24] 张海东, 王仁生. 中草药防治放射性口干症的研究进展[J]. 医学综述, 2012, 18(2): 272274. [25] Feng J, van der Zwaag M, Stokman MA, et al. Isolation and characterization of human salivary gland cells for stem cell transplantation to reduce radiationinduced hyposalivation[J]. Radiother Oncol, 2009, 92(3): 466471. [26] Nanduri LS, Maimets M, Pringle SA, et al. Regeneration of irradiated salivary glands with stem cell marker expressing cells[J]. Radiother Oncol, 2011, 99(3): 367372. [27] Lim JY, Yi T, Lee S, et al. Establishment and characterization of mesenchymal stem celllike clonal stem cells from mouse salivary glands[J]. Tissue Eng Part C Methods, 2014, 21(5):44757. [28] Sumita Y, Liu Y, Khalili S, et al. Bone marrowderived cells rescue salivary gland function in mice with head and neck irradiation[J]. Int J Biochem Cell Biol, 2011, 43(1): 8087. [29] Lee J, Park S, Roh S. Transdifferentiation of mouse adiposederived stromal cells into acinar cells of the submandibular gland using a coculture system[J]. Exp Cell Res, 2015, 334(1):160172. [30] Wang Z, Zourelias L, Wu C, et al. Ultrasoundassisted nonviral gene transfer of AQP1 to the irradiated minipig parotid gland restores fluid secretion[J]. Gene Ther, 2015, In press. |
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