%A 钟晨怡,冒韵东 %T 长非编码RNA在肿瘤细胞有氧糖酵解中的调控作用 %0 Journal Article %D 2019 %J 国际肿瘤学杂志 %R 10.3760/cma.j.issn.1673-422X.2019.03.008 %P 170-173 %V 46 %N 3 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_10608.shtml} %8 2019-03-08 %X Long noncoding RNA (lncRNA) is a kind of RNA with a length greater than 200 nucleotides and lacks proteincoding function. Varieties of lncRNAs have been found to play major roles in the aerobic glycolysis of tumor cells, such as lncRNAp21, H19, prostate specific transcript 1 (PGCEM1) and so on. In tumor cells, lncRNA can directly regulate the ratelimiting enzyme in the glycolytic pathway, also can indirectly regulate the glycolysis by hypoxia inducible factor1α (HIF1α) or protooncogene cmyc. Further study on the mechanism of lncRNA regulating tumor cell glycolysis is expected to open up new ideas for the diagnosis and treatment of tumor diseases.