Roles of Hippo-TAZ signaling pathway in breast cancer and breast cancer stem cells

Abstract

Abstract:Hippo signaling pathway plays an important role in the regulation of organ growth, tissue regeneration, tumor occurrence and development. Transcriptional coactivator with PDZbinding motif (TAZ) is the downstream transcription factor of Hippo signaling, participates in the regulation of the entire signaling pathway. In recent years, many studies have found that overexpression of TAZ has a close relationship with the occurrence, development and prognosis of breast cancer. Discussing the relationship of HippoTAZ with breast cancer and breast cancer stem cells may provide a new way for breast cancer diagnosis and treatment.

Key words:Breast neoplasms,Neoplastic stem cells,Hippo signaling,Transcriptional coactivator with PDZbinding motif

Yan Bing, Lu Ying, Zhang Chunying, Li Qing, Mao Jun, Li Lianhong. Roles of Hippo-TAZ signaling pathway in breast cancer and breast cancer stem cells[J]. Journal of International Oncology, 2016, 43(10): 779-782.

References

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