Correlation of AS160 hyperphosphorylation and 18FFDG uptaking in invasive breast cancer

Abstract

Abstract:ObjectiveTo investigate the correlation between AS160 hyperphosphorylation and 18Ffluorodeoxyglucose (18FFDG) uptaking in invasive breast cancer. MethodsThirtynine primary breast caner patients received PET/CT scan before operation and their maximum standard uptake values (SUVmax) were recorded. The levels of pAS160 (Thr642) were detected using immunohistochemical method in breast cancer tissues. The association between pAS160 (Thr642) levels and SUVmax was assessed using the Spearman nonparametric test. ResultsThe 18FFDG uptake of tumors of the 39 patients with primary breast caner was 6.1±2.7 (SUVmax). There was one false negative case in PET/CT scan imaging, compared with postoperative pathologic result. The positive rate of pAS160 (Thr642) was 76.9%, and it was positively correlated with SUVmax (r=0.672, P<0.001). ConclusionAS160 plays a significant role in the glucose metablism of breast cancer tissues and its hyperphosphorylation may contribute to the increased uptaking of glucose in patients with breast cancer.

Key words:Breast neoplasms,Phosphorylation,Fluomdeoxyglucose F18,AS160

Wei Yu, Jiang Xiaohua, Ma Ning, Cheng Yi, Lyu Guifang, Wang Wei, Zhao Jinfen. Correlation of AS160 hyperphosphorylation and 18FFDG uptaking in invasive breast cancer[J]. Journal of International Oncology, 2017, 44(3): 173-176.

References

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