Journal of International Oncology››2017,Vol. 44››Issue (12): 918-921.doi:10.3760/cma.j.issn.1673-422X.2017.12.009

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Epigenetic regulation of epithelial-mesenchymal transition

Li Wenqing, Hou Jinsong

  1. Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Online:2017-12-08Published:2017-12-01
  • Contact:Hou Jinsong, Email: houjs@mail.sysu.edu.cn E-mail:houjs@mail.sysu.edu.cn
  • Supported by:
    National Natural Science Foundation of China (81572660); Natural Science Foundation of Guangdong Province of China (2015A030313034)

Abstract:The hallmark of epithelial-mesenchymal transition (EMT) is the loss of E-cadherin. The downregulation of E-cadherin can be mediated by its transcriptional repression through the binding of EMT transcription factors to the E-cadherin promoter. Epigenetic mechanisms including DNA methylation, histone code and microRNAs are involved in the regulation of EMT-related genes. Studies have shown that EMT transcription factors can cooperate with several epigenetic modifiers to participate in the expression of E-cadherin. Targeting epigenetic regulation of EMT represents a new promising therapeutic direction.

Key words:DNA methylation,MicroRNAs,Histone code,Epithelial-mesenchymal transition