Journal of International Oncology››2017,Vol. 44››Issue (12): 926-928.doi:10.3760/cma.j.issn.1673-422X.2017.12.011

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Na+-K+-2Cl- cotransporter 1 and glioma

Ma Haiwen, Yu Shengping, Yang Xuejun.

  1. Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
  • Online:2017-12-08Published:2017-12-01
  • Contact:Yang Xuejun, Email: ydenny@126.com E-mail:ydenny@126.com
  • Supported by:
    National Natural Science Foundation of China (81472352, 81502171)

Abstract:Na+-K+-2Cl- cotransporter 1 (NKCC1) is highly expressed in malignant gliomas, which is closely related to the degree of malignancy. NKCC1 protein has a vital function in the volume regulation of glioma cells. NKCC1 allows glioma cells to transform its volume freely, migrating through the narrow extracellular space to achieve distant metastases. There is also close relationship between NKCC1 and tumor cytoskeleton regulation. In addition, NKCC1 is closely associated with cell cycle, nerve activity and other biological functions. In conclusion, NKCC1 plays an important role in gliomas.

Key words:Glioma,Na+-K+-2Cl- cotransporter 1