Journal of International Oncology››2017,Vol. 44››Issue (12): 937-939.doi:10.3760/cma.j.issn.1673-422X.2017.12.014

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Research progress of long noncoding RNA in gastric cancer

Zhang Guohua, Zhang Wenbo, Jiang Pengcheng

  1. Department of General Surgery, Affiliated People′s Hospital of Jiangsu University, Zhenjiang 212002, China
  • Online:2017-12-08Published:2017-12-01
  • Contact:Zhang Wenbo, Email: wb.zhan@hotmail.com E-mail:wb.zhan@hotmail.com
  • Supported by:
    National Natural Science Foundation of China (81500193); China Postdoctoral Science Foundation (2015M571703); Natural Science Foundation of Jiangsu Province of China (BK20161353)

Abstract:Long noncoding RNA (lncRNA) can extensively participate in the pathogenesis, proliferation, invasion and metastasis, apoptosis, angiogenesis, immunization, and drug resistance of gastric cancer through various mechanisms, including epigenetic regulation, variable splicing and competitive endogenous RNA. In addition, lncRNA has broad prospects in the diagnosis, targeted therapy and prognosis of gastric cancer.

Key words:Stomach neoplasms,Neoplasm metastasis,Long noncoding RNA