Journal of International Oncology››2019,Vol. 46››Issue (1): 45-48.doi:10.3760/cma.j.issn.1673-422X.2019.01.010

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Clinical application of Apatinib in the treatment of malignancies

Huang Hai, Bi Feng

  1. Department of Abdominal Oncology, West China Hospital, Sichuan University, Chengdu 610041, China
  • Received:2018-09-06Online:2019-01-08Published:2019-04-03
  • Contact:Bi Feng E-mail:bifeng@medmail.com.cn
  • Supported by:

    National Natural Science Foundation of China (81872020)

Abstract:Apatinib is a kind of antiangiogenesis drug of small molecular tyrosine kinase inhibitor, which can strongly against tumor angiogenesis by inhibiting vascular endothelial growth factor receptor 2 with highly selectivity. Apatinib can block cell cycle and reverse drug resistance. Clinical studies have shown that Apatinib is effective for many malignant tumors, including non-small-cell lung cancer, breast cancer and gastric cancer, which has encouraging objective response rate and survival benefit. Apatinib also has good safety and tolerance.

Key words:Neoplasms,Neovascularization, pathologic,Apatinib,Vascular endothelial growth factor receptor-2,Molecular targeted therapy