| ［1］ Egerman MA, Glass DJ. Signaling pathways controlling skeletal muscle mass［J］. Crit Rev Biochem Mol Biol, 2014, 49(1): 59-68. DOI: 10.3109/10409238.2013.857291. ［2］ Mendes MC, Pimentel GD, Costa FO, et al. Molecular and neuroendocrine mechanisms of cancer cachexia［J］. J Endocrinol, 2015, 226(3): R29-R43. DOI: 10.1530/JOE-15-0170. ［3］ 刘栋, 陈淑珍. 癌症恶病质与脂肪流失［J］. 中国生化药物杂志, 2016, 36(6): 6-9. DOI: 10.3969/j.issn.1005-1678.2016.06.02. ［4］ Fearon K, Strasser F, Anker SD, et al. Definition and classification of cancer cachexia: an international consensus［J］. Lancet Oncol, 2011, 12(5): 489495. DOI: 10.1016/S14702045(10)70218-7. ［5］ Vanhoutte G, van de Wiel M, Wouters K, et al. Cachexia in cancer: what is in the definition?［J］. BMJ Open Gastroenterol, 2016, 3(1): e000097. DOI: 10.1136/bmjgast-2016-000097. ［6］ Baltgalvis KA, Berger FG, Pena MM, et al. Interleukin6 and cachexia in ApcMin/+ mice［J］. Am J Physiol Regul Integr Comp Physiol, 2008, 294(2): R393-R401. DOI: 10.1152/ajpregu.00716.2007. ［7］ Trikha M, Corringham R, Klein B, et al. Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence［J］. Clin Cancer Res, 2003, 9(13): 46534665. ［8］ Onesti JK, Guttridge DC. Inflammation based regulation of cancer cachexia［J］. Biomed Res Int, 2014, 2014: 168407. DOI: 10.1155/2014/168407. ［9］ Castell JV, GómezLechón MJ, David M, et al. Acutephase response of human hepatocytes: regulation of acutephase protein synthesis by interleukin-6［J］. Hepatology, 1990, 12(5): 1179-1186. ［10］ McKeown DJ, Brown DJ, Kelly A, et al. The relationship between circulating concentrations of Creactive protein, inflammatory cytokines and cytokine receptors in patients with non-smallcell lung cancer［J］. Br J Cancer, 2004, 91(12): 1993-1995.DOI: 10.1038/sj.bjc.6602248. ［11］ Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation［J］. Cell, 2011, 144(5): 646-674. DOI: 10.1016/j.cell.2011.02.013. ［12］ Flint TR, Janowitz T, Connell CM, et al. Tumor-induced IL-6 reprograms host metabolism to suppress antitumor immunity［J］. Cell Metab, 2016, 24(5): 672-684. DOI: 10.1016/j.cmet.2016.10.010. ［13］ Kersten S, Seydoux J, Peters JM, et al. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting［J］. J Clin Invest, 1999, 103(11): 1489-1498. DOI: 10.1172/JCI6223. ［14］ Macciò A, Madeddu C, Massa D, et al. Hemoglobin levels correlate with interleukin6 levels in patients with advanced untreatedepithelial ovarian cancer: role of inflammation in cancerrelated anemia［J］. Blood, 2005, 106(1): 362-367. DOI: 10.1182/blood-2005-01-0160. |
