Journal of International Oncology››2019,Vol. 46››Issue (7): 420-422.doi:10.3760/cma.j.issn.1673-422X.2019.07.006

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Effect of ubiquitin-specific protease on radiosensitivity of tumor

Zhou Qifen1, Wu Chunlin2

  1. 1School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350000, China; 2Department of Pathology, Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China
  • Online:2019-07-08Published:2019-07-16
  • Contact:Wu Chunlin E-mail:wuchunlin120@sina.com

Abstract:Ubiquitin-specific protease is a member of the deubiquitinating enzyme family, which can reverse the ubiquitination of proteins and stabilize proteins. It affects radiosensitivity of tumor by regulating DNA damage, cell cycle, nuclear factor-κB signaling pathway, Nrf2-Keap1 signaling pathway and oncogene c-myc. It is expected to become a new target for tumor radiotherapy sensitization.

Key words:Neoplasms,Radiation tolerance,Ubiquitin specific proteases