Nilotinib in first-line treatment of chronic myeloid leukemia

Abstract

Abstract:

Chronic myeloid leukemia (CML) is a myeloproliferative tumor whose pathogenesis is related to the BCR/ABL fusion gene. Tyrosine kinase inhibitors (TKIs) can significantly improve the survival and prognosis of CML patients. Nilotinib is effective in first-line treatment of CML patients with rapid response, deep remission and high safety. After achieving a sustained deep molecular response, it is a new therapeutic goal for CML to stop the use of nilotinib and achieve treatment-free remission. In addition, due to disease resistance and mutations, how to start new treatments after nilotinib treatment failure is worth further research.

Key words:Leukemia,myeloid,chronic-phase,Tyrosine kinase inhibitor,Nilotinib

Hong Li, Wang Yu, Zhang Qi, Lyu Chengfang. Nilotinib in first-line treatment of chronic myeloid leukemia[J]. Journal of International Oncology, 2020, 47(1): 56-59.

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