Journal of International Oncology››2021,Vol. 48››Issue (1): 11-17.doi:10.3760/cma.j.cn371439-20201126-00002
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Received:2020-11-26Revised:2020-12-08Online:2021-01-08Published:2021-01-21
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| 肿瘤类型 | 化疗方案 | 建议 | |
|---|---|---|---|
| 小细胞肺癌 | ①CDE方案(环磷酰胺+多柔比星+依托泊苷) | ||
| ②拓扑替康 | |||
| ③ICE方案(异环磷酰胺+卡铂+依托泊苷) | |||
| 非小细胞肺癌 | DC方案(多西他赛+卡铂) | ||
| 肿瘤类型 | 化疗方案 | 建议 | |
| 结直肠癌 | FOLFOXIRI方案(氟尿嘧啶+亚叶酸钙+奥沙利铂+伊立替康) | ||
| 食管癌和胃癌 | DCF方案(多西他赛+顺铂+氟尿嘧啶) | ||
| 胰腺癌 | FOLFIRINOX方案(奥沙利铂+亚叶酸+伊立替康+氟尿嘧啶) | ||
| 卵巢癌 | ①托泊替康 | ||
| ②紫杉醇 | |||
| ③多西他赛 | |||
| 头颈部肿瘤 | TPF方案(多西他赛+顺铂+氟尿嘧啶) | ||
| 乳腺癌 | ①TCH方案(多西他赛+卡铂+曲妥珠单抗) | ||
| ②ddAC-2wP方案(剂量密集多柔比星+环磷酰胺+序贯紫杉醇双周) | |||
| ③ddAC-2wP方案(剂量密集多柔比星+环磷酰胺+序贯紫杉醇单周) | |||
| ④TAC方案(多西他赛+多柔比星+环磷酰胺) | |||
| ⑤TE方案(多西他赛+表柔比星) | |||
| ⑥TC方案(多西他赛+环磷酰胺) | |||
| ⑦FEC方案(氟尿嘧啶+表柔比星+环磷酰胺) | |||
| ⑧高剂量多西他赛+噻替哌+卡铂联合 | |||
| ⑨高剂量多西他赛+噻替哌联合 | |||
| 肾癌 | 多柔比星+吉西他滨 | ||
| 睾丸癌 | ①VeIP方案(长春碱+异环磷酰胺+顺铂) | ||
| ②VIP方案(依托泊苷+异环磷酰胺+顺铂) | |||
| ③TIP方案(紫杉醇+异环磷酰胺+顺铂) | 建议预防性应用 | ||
| 膀胱癌 | 剂量密集的MVAC(甲氨蝶呤+长春碱+多柔比星+顺铂) | PEG-rhG-CSF | |
| 霍奇金淋巴瘤 | ①BEACOPP方案(博来霉素+依托泊苷+多柔比星+环磷酰胺+长春新碱+丙卡巴肼+泼尼松) | ||
| ②Brentuximabvedotin(维汀-布仑妥昔单抗)+AVD方案(多柔比星+长春碱+达卡巴嗪) | |||
| 非霍奇金淋巴瘤 | ①ICE方案(异环磷酰胺+卡铂+依托泊苷) | ||
| ②剂量调整的EPOCH方案(依托泊苷+泼尼松+长春新碱+环磷酰胺+多柔比星) | |||
| ③剂量密集的CHOP方案(环磷酰胺+多柔比星+长春新碱+泼尼松)±利妥昔单抗 | |||
| ④MINE方案(美司钠+异环磷酰胺、米托蒽醌+足叶乙甙) | |||
| ⑤DHAP方案(地塞米松+顺铂+阿糖胞苷) | |||
| ⑥ESHAP方案(依托泊苷+甲泼尼龙+顺铂+阿糖胞苷) | |||
| ⑦高剂量HyperCVAD方案(环磷酰胺+长春新碱+多柔比星+地塞米松)±利妥昔单抗 | |||
| 黑色素瘤 | ①以达卡巴嗪为主的联合方案(达卡巴嗪+顺铂+长春碱) | ||
| ②以达卡巴嗪为主联合IL-2、干扰素α的方案(达卡巴嗪+顺铂+长春碱+IL-2+干扰素α) | |||
| 骨肉瘤 | ①高剂量异环磷酰胺联合高剂量甲氨蝶呤 | ||
| ②多柔比星和顺铂(新辅助) | |||
| ③甲氨蝶呤、多柔比星和顺铂(初诊为高级别) | |||
| ④甲氨蝶呤、多柔比星和顺铂联合异环磷酰胺、依托泊苷(初诊为高级别) | |||
| ⑤顺铂动脉介入联合多柔比星静脉滴注 | |||
| ⑥顺铂动脉介入联合多柔比星、异环磷酰胺静脉滴注 | |||
| 软组织肉瘤 | ①MAID方案(美司钠+多柔比星+异环磷酰胺+达卡巴嗪) | ||
| ②标准剂量多柔比星或高剂量表柔比星 | |||
| ③异环磷酰胺和多柔比星 | |||
| 多发性骨髓瘤 | ①DT-PACE方案(地塞米松+沙利度胺+顺铂+多柔比星+环磷酰胺+依托泊苷) | ||
| ②VTD-PACE方案(DT-PACE方案+硼替佐米) | |||
"
| 肿瘤类型 | 化疗方案 | 风险因素评估 | 建议 |
|---|---|---|---|
| 小细胞肺癌 | ①CAV方案(环磷酰胺+多柔比星+长春新碱) | ①年龄>65岁并接受足剂量 强度化疗 ②既往接受过化疗或放疗 ③治疗前已经存在中性粒 细胞减少 ④肿瘤疾病累及骨髓 ⑤近期外科手术和/或开放性 创伤 ⑥肝功能障碍(胆红素> 20 mg/L) ⑦肾功能障碍(肌酐清除率< 50 mg/min) ⑧既往发生过FN ⑨恶性血液淋巴系统疾病 ⑩女性患者(小细胞肺癌) ⑪心血管疾病(非霍奇金淋巴瘤) |
若患者出现≥1项风险因素时,需要考虑给予预防性应用PEG-rhG-CSF |
| ②依托泊苷+顺铂/卡铂 | |||
| 非小细胞肺癌 | ①TP方案(紫杉醇+顺铂) | ||
| ②NP方案(顺铂+长春瑞滨) | |||
| ③DP方案(顺铂+多西他赛) | |||
| ④顺铂 | |||
| ⑤依托泊苷 | |||
| ⑥CP方案(卡铂+紫杉醇) | |||
| ⑦多西他赛 | |||
| 结直肠癌 | FOLFOX方案(氟尿嘧啶+亚叶酸钙+奥沙利铂) | ||
| 食管癌和胃癌 | ①伊立替康、顺铂 | ||
| ②表柔比星、顺铂、氟尿嘧啶 | |||
| ③表柔比星、顺铂、卡培他滨 | |||
| 胰腺癌 | FOLFIRINOX方案(奥沙利铂+亚叶酸+伊立替康+氟尿嘧啶) | ||
| 卵巢癌 | 卡铂和多西他赛 | ||
| 宫颈癌 | ①顺铂和托泊替康 | ||
| ②紫杉醇和顺铂 | |||
| ③托泊替康 | |||
| ④伊立替康 | |||
| 子宫肉瘤 | 多西他赛 | ||
| 乳腺癌 | ①含多西他赛的方案±曲妥珠单抗 | ||
| ②CMF方案(环磷酰胺+甲氨蝶呤+氟尿嘧啶) | |||
| ③AC-T方案(多柔比星+环磷酰胺序贯多西他赛,仅多西他赛治疗周期) | |||
| ④AC-TH方案(多西他赛序贯给药+曲妥珠单抗) | |||
| ⑤FEC-T方案(氟尿嘧啶+表柔比星+环磷酰胺序贯多西他赛) | |||
| ⑥紫杉醇21 d方案 | |||
| ⑦ddEC-T方案(剂量密集表柔比星+环磷酰胺序贯紫杉醇) | |||
| ⑧E-CMF方案(表柔比星序贯环磷酰胺+甲氨蝶呤+氟尿嘧啶) | |||
| ⑨XT方案(卡培他滨+多西他赛标准方案) | |||
| 睾丸癌 | ①依托泊苷和顺铂 | ||
| ②BEP方案(博来霉素+依托泊苷+顺铂) | |||
| 前列腺癌 | 卡巴他赛 | ||
| 非霍奇金淋巴瘤 | ①GDP方案(吉西他滨+地塞米松+顺铂)±利妥昔单抗 | ||
| ②CHOP方案(环磷酰胺+多柔比星+长春新碱+泼尼松)±利妥昔单抗,包括含聚乙二醇脂质体多柔比星替代多柔比星的治疗方案 | |||
| ③CHP方案(环磷酰胺+多柔比星+泼尼松)+本妥昔单抗 | |||
| ④苯达莫司汀 |
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