Journal of International Oncology››2021,Vol. 48››Issue (9): 572-.doi:10.3760/cma.j.cn371439-20201201-00112

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Research progress of arsenic trioxide in anti-liver cancer mechanism and treatment of hepatocellular carcinoma

Du Jiahang, Chen Dong, Chen Yaoting()

  1. Department of Interventional Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
  • Received:2020-12-01Revised:2021-01-06Online:2021-09-08Published:2021-09-22
  • Contact:Chen Yaoting E-mail:chenyaot@mail.sysu.edu.cn

Abstract:

Arsenic trioxide (ATO) is involved in a variety of biological processes of hepatocellular carcinoma (HCC) cells, including apoptosis induction, proliferation inhibition, invasion and metastasis inhibition, and tumor stem cell inhibition. ATO has a variety of therapeutic approaches in the treatment of HCC, mainly including single drug therapy, combined local therapy, combined systemic therapy, and so on. Further research on the anti-cancer mechanism and clinical application of ATO is expected to provide new ideas for the treatment of liver cancer.

Key words:Liver neoplasms,Therapeutic uses,Arsenic trioxide