Research progress of memantine hydrochloride in the treatment of radiation-induced cognitive dysfunction and its combined application with vitamins

Abstract

Abstract:

Radiation-induced cognitive dysfunction （RICD） has an insidious onset and there is a lack of effective prevention and treatment measures. The efficacy of memantine hydrochloride as a classical treatment drug is limited， and it is inevitable to seek multi-target combination drugs. In recent years， the protective effect of vitamin E and vitamin D on cognitive function has been widely recognized. Several basic studies have shown that vitamin E can play a role in the combination of medication by protecting neurons and reducing the adverse effects caused by memantine hydrochloride； Vitamin D and memantine hydrochloride have also become a hot topic of research due to their significant synergistic effects. The combination of memantine hydrochloride and vitamin therapy is expected to bring additional benefits to RICD patients.

Key words:Radiotherapy,Cognitive dysfunction,Memantine,Vitamins

Wang Jin, Li Ruoyang, Zhao Xuewei, Li Hui, Zhou Zhiguo, Zhao Jingxia. Research progress of memantine hydrochloride in the treatment of radiation-induced cognitive dysfunction and its combined application with vitamins[J]. Journal of International Oncology, 2023, 50(10): 622-626.

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