Research progress of tumor microenvironment mediated drug resistance in targeted therapy of breast cancer

Abstract

Abstract:

Targeted therapy for breast cancer can significantly improve the prognosis， quality of life and survival of breast cancer patients， but the emergence of primary or acquired drug resistance will eventually lead to disease progression， recurrence or metastasis. Tumor microenvironment （TME） is a complex environment for breast cancer cells to survive. Breast cancer cells and TME are currently known to be a functional whole， and the crosstalk between them plays a key role in breast cancer progression and resistance to targeted therapies. Therefore， clarifying TME abnormalities is important to reveal the underlying mechanisms of targeted therapy resistance and to develop therapeutic strategies against targeted therapy-resistant malignancies.

Key words:Breast neoplasms,Tumor microenvironment,Molecular targeted therapy,Drug resistance,neoplasm

Yang Zhi, Lu Yiqiao, Gu Huayan, Ding Jialing, Guo Guilong. Research progress of tumor microenvironment mediated drug resistance in targeted therapy of breast cancer[J]. Journal of International Oncology, 2024, 51(4): 235-238.

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