Journal of International Oncology››2012,Vol. 39››Issue (7): 529-532.

Previous ArticlesNext Articles

Regulatory relationships between microRNAs and DNA methylation in gastric cancer

GU Yong-Juan, ZHAO Qiu, GUO Ren-Hua

  1. Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Online:2012-08-06Published:2012-08-06
  • Contact:GUO Ren-hua, E-mail: rhguo@njmu.edu.cn E-mail:rhguo@njmu.edu.cn

Abstract:MicroRNAs (miRNAs) are a class of small (22 nucleotides) noncoding RNAs which play important roles in diverse biological and pathological processes. The dysregulation of miRNA expression is closely related to the development and progression of malignant tumors in humans. DNA methylation is a kind of epigenetic modification in human genome. Both hypermethylation and hypomethylation of DNA are closely related to different kinds of tumors, including gastric cancer.

Key words:Stomach neoplasms,MicroRNAs,DNA methylation