Abstract:NDUFS3 is an essential subunit of mitochondrial NADH: ubiquinone oxidoreductase (complex Ⅰ) and plays a critical role in the mitochondrial type Ⅰrespiration chain. Mutations in this gene are shown to cause neurodegenerative disease such as Leigh syndrome(subacute necrotizing encephalopathy). In recent years, many evidences show that the expression of NDUFS3 proteins are lower in many cancerous cells compared to the corresponding normal cells. It comes to the conclusion that NDUFS3 may play a role in the tumorigenesis. 

Key words:Mitochondria,Neoplasms,Proteins