Journal of International Oncology››2012,Vol. 39››Issue (8): 683-686.

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CXCL12/CXCR4 and breast cancer

XU Shuang-Fei, ZHUANG Zhi-Gang

  1. Department of Breast Surgery, Shanghai First Maternal and Infant HealthCare Hospital, Shanghai 200040, China
  • Online:2012-09-22Published:2012-09-24

Abstract:CXCL12 and its receptor CXCR4 can express in breast cancer, and are regulated by several factors in the genesis and development of breast cancer. Lots of researches have proved that CXCL12 and CXCR4 can be used as new independent prognostic makers of breast cancer. Treatment targeted for CXCR4 can be seen as a new kind of combination therapy, which may provides patients a more ideal treatment.

Key words:Chemokine CXCL12,CXCR4 Receptor,Breast neoplasms