Abstract:The etiology of familial gastric cancer (FGC) are E-cadherin (CDH1) mutations, helicobacter pylori infection, etc. The median age of patients with FGC is 50—65 years old. The male-female sex ratio is 2:1. The most of tumors of FGC locate in distal stomach and present diffuse type in histological classification. It is reported that the people who has a family history of gastric cancer especially for those parents has an increased risk of gastric cancer. It is difficult to find FGC in early stage by current technology. The preventive methods include eradication of helicobacter pylori and prophylactic total gastrectomy, etc.

Key words:Stomach neoplasms,Family,Heredity