Journal of International Oncology››2013,Vol. 40››Issue (3): 174-176.

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Advances of PRDM genes and DNA methylation in cancer

TAN Yong-Li, TAN Shuang-Xiang, HU Rui-Cheng

  1. TAN Yong-li, TAN Shuang-xiang, HU Rui-cheng.Postgraduate School, University of South China, Hengyang 421001, China

  • Online:2013-03-08Published:2013-02-25
  • Contact:HU Rui-cheng, E-mail: huruicheng@hotmail.com E-mail:huruicheng@hotmail.com

Abstract:PRDI-BF1 and RIZ homology domain containing proteins (PRDM) play a key role in cell differentiation and proliferation. Most members of the PRDM gene family are tumor suppressor genes which involved in tumorigenesis and abnormal expression in a variety of tumors. Aberrant DNA methylation often silences these genes, which may occur in the early stage of tumor. Cancer can be reversed by demethylation, which provides a new way for cancer treatment.

Key words:DNA methylation,Genes, tumor suppressor,Neoplasms,PRDM genes