Journal of International Oncology››2013,Vol. 40››Issue (8): 643-645.

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Serum thymidine kinase 1 and cancer

XU Wen-Jing, LIU De-Gan

  1. Department of Oncology, Xinghua People's Hospital of Jiangsu Province, Xinghua 225700, China
  • Online:2013-09-08Published:2013-09-16
  • Contact:Corresponding author: XU Wen-jing, E-mail: 2007xuwenjing@163.com E-mail:2007xuwenjing@163.com

Abstract:Thymidine kinase 1 (TK1), an enzyme of the pyrimidine remedial pathway, can catalyze phosphorylation of thymidine to thymidine monophosphate. It is closely related to cell cycle regulation and cell proliferation. A number of experiments show that TK1 can be used for physical examination, tumor screening, routine testing, effect monitoring and prognosis, which is considered to be a sensitive and useful marker for human tumor growth.

Key words:Neoplasms,Thymidine kinase,Immunohistochemistry