Abstract:In order to make a rational andeffectivecure measure for lung cancer, we need to establishsuitableanimal model. Spontaneous or induced model needs long time to form tumor and therateis not steady. Xenograft mouse model is widely used inlaboratoriesbecause of its steadytumorformationrateand less time in oncogenesis. Engineered mouse model whichis based ongenetic technologynot only helps us tounderstandpathological processof lung cancer, but also can provide an ideal preclinical model oftargetedtherapyexperiment, and it will be theimportantdevelopment directionof lung canceranimal model.

Key words:Lung neoplasms,Models, animal