Journal of International Oncology››2013,Vol. 40››Issue (12): 924-926.doi:10.3760/cma.j.issn.1673-422X.2013.12.014

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Epithelial-mesenchymal transition and gastric cancer

LIU Li-Min, LI Ji-Kun

  1. Department of General Surgery, Affiliated First People′s Hospital of Shanghai Jiao Tong University, Shanghai 200080, China
  • Online:2013-12-10Published:2013-12-26
  • Contact:LI Ji-Kun E-mail:jkli65975@163.com

Abstract:Epithelialmesenchymal transition (EMT) is that cells undergo a switch from epithelial phenotype to mesenchymal phenotype. Recent researches show that EMT can affect the occurrence and development of gastric cancer through a variety of mechanisms and promote the migration and invasion of tumor cells. The process of EMT involves a number of signal transduction pathways, and is related to microRNAs, Helicobacter pylori, transcription factors and so on. EMT is expected to be a novel therapeutic target of gastric cancer.

Key words:Stomach neoplasms,Signal transduction,Neoplasm metastasis,Epithelial-mesenchymal transition