Journal of International Oncology››2013,Vol. 40››Issue (11): 843-846.doi:10.3760/cma.j.issn.1673-422X.2013.11.013

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Reversal for acquired resistance to EGFR inhibitors in lung cancer

LI Chen-Chen, FENG Ji-Feng

  1. Clinical Oncology Center, Affiliated Jiangsu Cancer Hospital of Nanjing Medical University, Nanjing 210009, China
  • Online:2013-11-08Published:2013-10-15
  • Contact:FENG Ji-feng, E-mail:fjif@medmail.com.cn E-mail:fjif@medmail.com.cn

Abstract:Epidermal growth factor receptor (EGFR) inhibitors targeted therapy is the forward position means for nonsmall cell lung cancer. However, acquired resistance to EGFR inhibitors limits the development of targeted drugs. Using existing data on drug resistance in EGFRmutant lung cancer, this review discusses three basic approaches for overcoming resistance to EGFRtargeted therapies: intensification of EGFR inhibition, combination of EGFR inhibitors with other targeted therapies, and altering clinical management via alternate pathways.

Key words:Lung neoplasms,Receptor,epidermal growth factor,Drug resistance,Inhibitors