Journal of International Oncology››2014,Vol. 41››Issue (3): 209-211.doi:10.3760/cma.j.issn.1673-422X.2014.03.015

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Maspin gene and the invasion and metastasis of gastric cancer

LIANG Hai-Peng, YANG Qing-Wei

  1. Department of Oncological Surgery, Qingyang People’s Hospital of Gansu Province, Qingyang 745000, China
  • Online:2014-03-08Published:2014-03-17
  • Contact:Liang Haipeng, E-mail: qylhp@126.com E-mail:qylhp@126.com

Abstract:The maspin gene, a tumor suppressor gene and a member of the serpin superfamily, is isolated from mammary epithelial cells. Maspin gene plays an important role in the process of invasion and metastasis of gastric cancer. Researches show that maspin gene suppresses the occurrence, development and metastasis of gastric cancer mainly by inducing tumor cell apoptosis, inhibiting tumor angiogenesis, methylation modification, promoting homogeneity adhesion and inhibiting heterogeneous adhesion

Key words:Maspin gene,Stomach neoplasms,Neoplasm invasiveness,Neoplasm metastasis