Abstract:Objective To explore the relationship between single nucleotide polymorphisms (rs12953717) of SMAD7 and susceptibility of non-small-cell lung cancer (NSCLC) in Chinese Han population. MethodsA single nucleotide polymorphisms (rs12953717) from SMAD7 was detected via Sequenom system in 528 NSCLC cases and 762 healthy controls. Data was statistically analyzed by unconditional Logistic regression method. Resultsrs12953717 had significant differences between nonsmall cell lung cancer patients and the controls. Compared with CC/TT (CC combined with TT) genotype, the adjusted odds ratio for the CT genotype was 4.107 (95%CI：3.206~5.260, P=0.000 1). Smokers had a 2.004 odds ratio (95%CI=1.583~2.537, P=0.000 1) of NSCLC compared with the controls. There was a 10.074fold increased risk of NSCLC among the subjects with CT genotype and smokers. Conclusion The polymorphism of rs12953717 may have relation with risk of NSCLC. Heterozygote (CT) is a susceptibility genotype of NSCLC. Smoking is one of the risk factors of NSCLC. Smoking and CT genotype have synergistic effects on NSCLC susceptibility.

Key words:Polymorphism, single nucleotide,Smoking,Carcinoma, non-small-cell lung,Disease susceptibility,SMAD7