Abstract:Epigenetics refers to heritable alterations in gene expression that do not involve the DNA coding sequence itself. Epigenetic regulation plays an important role in gene expression, DNA replication, reparation and reconstitution. Thus, the abnormity of epigenetic regulation may lead to different diseases, especially cancer. SNF5, which can suppress tumor significantly, is one of the core components of SWI/SNF chromosome remodeling complexes. EZH2, a histone methyltransferase, is closely and complicatedly related to cancer and has significant effect on tumorigenesis. There are many studies reporting the effects of epigenetic regulation factors—SNF5 and EZH2 on different tumors as well as the interrelation at present. In the present paper, the advances in the research on these two epigenetic regulation factors in the carcinogenesis are reviewed.

Key words:Epigenesis,genetic,Neoplasms,Gene silencing,EZH2