Journal of International Oncology››2015,Vol. 42››Issue (1): 49-51.doi:10.3760/cma.j.issn.1673-422X.2015.01.013

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Radiotherapy sensitization mechanisms of tumor necrosis factor-α

Ge Yizhi, Wang Buhai, Xu Lichun

  1. Center for Cancer Research on Prevention and Treatment, Medical College of Yangzhou University, Yangzhou 225001, China
  • Received:2014-06-10Revised:2014-08-04Online:2015-01-08Published:2015-01-07
  • Contact:Xu Lichun E-mail:732718420@qq.com

Abstract:Tumor necrosis factor-α (TNF-α)is a kind of cytokines with a wide range of biological activity, which is closely related to the occurrence and development of various diseases. Nowadays, a number of researchers use TNFα as a radiationsensitizing agent to evaluate the effect of radiation sensitivity of tumor cells. The scheme may have correlation with cell apoptosis, cell cycle, hypoxic cells, repair of DNA damage, etc.

Key words:Tumor necrosis factor-α,Radiotherapy,Radiation sensitizing agents