Journal of International Oncology››2014,Vol. 41››Issue (11): 824-827.doi:10.3760/cma.j.issn.1673-422X.2014.11.008

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Vasculogenic mimicry in cancer

  1. Department of Breast Surgery, Affiliated Shengjing Hospital of China Medical University, Shenyang 110004, China
  • Online:2014-12-03Published:2015-01-20
  • Contact:Zhang Wenhai, Email: zhangwh@sj-hospital.org

Abstract:Vasculogenic mimicry (VM) is one of the blood supply patterns in malignant tumor, and the molecular mechanism of breast malignant tumor VM is complicated. The plasticity of tumor cells and variety of molecules regulation play important roles in the mechanism of VM. At the same time, the hypoxic microenvironment and microRNA (miRNA) are associated with the occurrence and development of VM, especially in breast malignant tumor, and they are expected to become important diagnostic and prognostic indicators in breast cancer.

Key words:Breast neoplasms,Vascular endothelial growth factors; ,Hypoxia inducible factor 1, alpha subunit,MicroRNAs,Vasculogenic mimicry