Journal of International Oncology››2014,Vol. 41››Issue (12): 909-912.doi:10.3760/cma.j.issn.1673-422X.2014.12.010

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Research progress of ERCC1 in non-small cell lung cancer based on the platinum drugs

  1. Department of Oncology, Center Hospital of Cang zhou of Heibei Province, Cang zhou 061001, China
  • Online:2014-12-24Published:2015-02-02
  • Contact:Liu Zhibao, Email: liuzhibao1981@163.com

Abstract:Excision repair cross complementing group 1 (ERCC1) gene is an enzyme of the speed limit of DNA repair protein in nucleotide excision repair (NER) pathways.Researches suggest that ERCC1 has been associated with cisplatin resistance in nonsmall cell lung cancer (NSCLC) patients. Thus, ERCC1 gene is a new target in malignant tumor gene therapy research,providing a new approach for the treatment of malignant,especially NSCLC.

Key words:Cisplatin,Carcinoma, Nonsmall cell lung,Excision repair cross complementing group 1