Targeted therapy for small cell lung cancer

Abstract

Wang Wenxian, Zhang Yiping. Targeted therapy for small cell lung cancer[J]. Journal of International Oncology, 2015, 42(6): 452-454.

［1］ Kalemkerian G, Akerley W, Bogner P, et al. Small cell lung cancer［J］. Natl Compr Canc Netw, 2013, 11(1): 78-98. ［2］ Wojcik E, Jakubowicz J, Skotnicki P, et al. IL6 and VEGF in small cell lung cancer patients［J］. Anticancer Res, 2010, 30(5): 1773-1778. ［3］ Horn L, Dahlberg S, Sandler A, et al. Phase Ⅱ study of cisplatin plus etoposide and bevacizumab for previously untreated, extensivestage smallcell lung cancer［J］. J Clin Oncol, 2009, 27(35): 6006-6011. ［4］ Ready N, Dudek A, Pang H, et al. Cisplatin, irinotecan, and bevacizumab for untreated extensivestage smallcell lung cancer: CALGB 30306, a phase Ⅱ study［J］. J Clin Oncol, 2011, 29(33): 4436-4441. ［5］ Spigel D, Townley P, Waterhouse D, et al. Randomized phase Ⅱ study of bevacizumab in combination with chemotherapy in previously untreated extensivestage smallcell lung cancer: results from the SALUTE trial［J］. J Clin Oncol, 2011, 29(16): 2215-2222. ［6］ Pujol J, Lavole A, Quoix E, et al. Randomized phase Ⅱ/Ⅲ study of bevacizumab in combination with chemotherapy in previously untreated extensive smallcell lung cancer: IFCT0802 trial［J］. J Clin Oncol, 2014, 32(15): 478-478. ［7］ Lu S, Li L, Luo Y, et al. Randomized phase Ⅱ study of recombinant human endostatin in combination with chemotherapy in previously untreated extensivestage smallcell lung cancer (NCT00912392)［J］. J Clin Oncol, 2012, 30(15): 98-102. ［8］ Rachel E, Sanborn J, Patel G, et al. A randomized doubleblind phase Ⅱ trial of platinum plus etoposide with or without cocurrent ZD6474(Z) in patients with previously untreated extensivestage small cell lung cancer: Hoosier Oncology Group LUN06113［J］. J Clin Oncol, 2014, 32(15s): 7506. ［9］ Schneider B, Gadgeel S, Ramnath N, et al. Phase Ⅱ trial of sunitinib maintenance therapy after platinumbased chemotherapy in patients with extensivestage small cell lung cancer［J］. J Thorac Oncol, 2011, 6(6): 1117-1120. ［10］ Han J, Kim H, Lim K, et al. A phase Ⅱ study of sunitinib in patients with relapsed or refractory small cell lung cancer［J］. Lung Cancer, 2013, 79(2): 137-142. ［11］ David R, Spigel A, Spira R, et al. PhaseⅠb of anticancer stem cell antibody OMG59R5 in combination with etoposide and cisplatin in patients with untreated extensivestage small cell lung cancer［J］. J Clin Oncol, 2014, 32(15s): 7601. ［12］ Schmid K, BagoHorvath Z, Berger W, et al. Dual inhibition of egfr and mtor pathways in small cell lung cancer［J］. Br J Cancer, 2010, 103(5): 622-628. ［13］ Tarhini A, Kotsakis A, Gooding W, et al. Phase Ⅱ study of everolimus (RAD001) in previously treated small cell lung cancer［J］. Clin Cancer Res, 2010, 16(23): 5900-5907. ［14］ Besse B, Heist R, Papadmitrakopoulou V, et al. A phaseⅠb doseescalation study of everolimus combined with cisplatin and etoposide as firstline therapy in patients with extensivestage smallcell lung cancer［J］. Ann Oncol, 2014, 25(2): 505-511. ［15］ Tibes R, Fine G, Choy G, et al. A phase Ⅰ firstinhuman doseescalation study of amuvatinib, a multitargeted tyrosine kinase inhibitor, in patients with advanced solid tumors［J］. Cancer Chemother Pharmacol, 2013, 71(2): 463-471. ［16］ Mita M, Gordon M, Rosen L, et al. Phase Ⅰb study of amuvatinib in combination with five standard cancer therapies in adults with advanced solid tumors［J］. Cancer Chemother Pharmacol, 2014, 74(1): 195-204. ［17］ Park K, Martelotto L, Peifer M, et al. A crucial requirement for Hedgehog signaling in small cell lung cancer［J］. Nat Med, 2011, 17(11): 1504-1508. ［18］ Maria C, Lee M, Krug A, et al. Phase Ⅰ trial of the hedgehog inhibitor, LDE225, in combination with etoposide and cisplatin for initial treatment of extensive stage small cell lung cancer［J］. J Clin Oncol, 2014, 32(5s): 7602. ［19］ Langer C, Albert L, Kovacs P, et al. Randomized phase Ⅱ study of carboplatin and etoposide with or without obatoclax mesylate in extensivestage small cell lung cancer［J］. Lung Cancer, 2014, 85(3): 420-428. ［20］ Paik P, Rudin C, Pietanza M, et al. A phase Ⅱ study of obatoclax mesylate, a BCL2 antagonist, plus topotecan in relapsed small cell lung cancer［J］. Lung Cancer, 2011, 74(3): 481-485. ［21］ Baggstrom M, Qi Y, Koczywas M, et al. A phase Ⅱ study of AT101 (Gossypol) in chemotherapysensitive recurrent extensivestage small cell lung cancer［J］. J Thorac Oncol, 2011, 6(10): 1757-1760. ［22］ Schelman W, Mohammed T, Traynor A, et al. A phase Ⅰ study of AT101 with cisplatin and etoposide in patients with advanced solid tumors with an expanded cohort in extensivestage small cell lung cancer［J］. Invest New Drugs, 2014, 32(2): 295-302.

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Targeted therapy for small cell lung cancer

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