Meta-analysis of the association between GSTT1 and the susceptibility to colorectal cancer among Chinese population

Abstract

Abstract:Objective To assess the association between glutathione S-transferase T1 （GSTT1) gene and the susceptibility of colorectal cancer among Chinese population. Methods Clinical controlled trials of the association between GSTT1 and the susceptibility of colorectal cancer among Chinese population were searched in PubMed, EMBase, Cochrane Library, China Biology Medicine disc, VIP database, China National Knowledge Infrastructure and Wanfang database. According to the inclusion and exclusion criteria, data extraction and quality assessment were done by two researchers independently. Outcomes were pooled with RevMan 5.1. Results 326 studies were found and 10 clinical controlled trails including 2 983 cases of colorectal cancer and 4 386 cases of healthy objects were included in this analysis. The results of Metaanalysis showed that the lack of GSTT1 gene is associated with colorectal cancer susceptibility (RR=1.11， 95%CI： 1.061.17， Z=4.26, P<0.000 1). Conclusion The loss of GSTT1 increase the risk of colorectal cancer among Chinese population.

Key words:Colonic neoplasms,Meta-analysis,Glutathione S-transferases T1

YANG Tian-Ning, ZHAO Da, MA Shou-Cheng, GUAN Quan-Lin. Meta-analysis of the association between GSTT1 and the susceptibility to colorectal cancer among Chinese population[J]. Journal of International Oncology, 2015, 42(10): 743-746.

References

［1］ Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012［J］. CA Cancer J Clin, 2015, 65(2): 87-108. ［2］ Vogtmann E, Xiang YB, Li HL, et al. Cruciferous vegetables, glutathione S-transferase polymorphisms, and the risk of colorectal cancer among Chinese men［J］. Ann Epidemiol, 2014, 24(1): 44-49. ［3］ Ketterer B. Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis［J］. Mutat Res, 1988, 202(2): 343-361. ［4］ Cong N, Liu L, Xie Y, et al. Association between glutathione S,transferase T1, M1, and P1 genotypes and the risk of colorectal cancer［J］. J Korean Med Sci, 2014, 29(11): 1488-1492. ［5］ Yang G, Gao YT, Shu XO, et al. Isothiocyanate exposure, glutathione Stransferase polymorphisms, and colorectal cancer risk［J］. Am J Clin Nutr, 2010, 91(3): 704-711. ［6］ Yeh CC, Hsieh LL, Tang R, et al. Vegetable/fruit, smoking, glutathione Stransferase polymorphisms and risk for colorectal cancer in Taiwan［J］. World J Gastroenterol, 2005, 11(10): 1473-1480. ［7］ Yeh CC, Lai CY, Hsieh LL, et al. Protein carbonyl levels, glutathione S,transferase polymorphisms and risk of colorectal cancer［J］. Carcinogenesis, 2010, 31(2): 228-233. ［8］ Zhu Y, Deng C, Zhang Y, et al. The relationship between GSTM1, GSTT1 gene polymorphisms and susceptibility to sporadic colorectal adenocarcinoma［J］. Zhonghua Nei Ke Za Zhi, 2002, 41(8): 538-540. ［9］付全航. 谷胱苷肽转硫酶M1、T1和P1基因多态性与江苏人群结直肠癌易感性的关系［D］. 南京：南京医科大学, 2007. ［10］陈坤, 蒋沁婷, 马新源, 等. 谷胱甘肽转移酶T1和M1基因多态性及吸烟与结直肠癌关系的对照研究［J］. 中华肿瘤杂志, 2004, 26(11): 645-648. ［11］黄立荣. GSTM1、GSTT1基因多态性与结直肠肿瘤易感性的研究［D］. 福州：福建医科大学, 2007. ［12］黄萍, 周紫垣, 马恒太, 等. 重庆地区人群GSTT1和GSTM1基因多态性与结直肠癌易感性研究［J］. 第三军医大学学报, 2003, 25(19): 1710-1713. ［13］黄雪, 谭至柔, 张瑜红. GSTM1、GSTT1基因多态性与广西壮族结直肠癌易感性的关系［J］. 广西医科大学学报, 2012, 29（1）: 106-108. ［14］ Funke S, Risch A, Nieters A, et al. Genetic polymorphisms in genes related to oxidative stress (GSTP1, GSTM1, GSTT1, CAT, MnSOD, MPO, eNOS) and survival of rectal cancer patients after radiotherapy［J］. J Cancer Epidemiol, 2009, 2009: 302047.

[1]	Chu Xuelei, Mao Yun, Xue Peng, Li Linlu, Chen Meichi, Yuan Chunsheng, Qin Xiaoyan, Zhu Shijie.Effects of chemotherapy dose intensity on short-term efficacy in patients with advanced colon cancer： a study based on real-world data[J]. Journal of International Oncology, 2022, 49(7): 408-415.
[2]	Laibijiang Wusiman, Cao Bowei, Zhang Wenbin, Gao Hua.Effects of exogenous AGR2 on the proliferation and invasion abilities of colon cancer cells[J]. Journal of International Oncology, 2022, 49(2): 73-78.
[3]	Li Qianqian, Zhu Xiaodi, Zhao Ronglan, Peng Xiaoxiang.Role of P2X7 receptor in colon cancer progression[J]. Journal of International Oncology, 2021, 48(4): 250-253.
[4]	Zhou Huiping, Li Yuhua, Wang Yuhui, Su Yilong, Yang Yingying, Xu Xiaotian, Duan Xiaoqun.Preventive and therapeutic effects of common plant drugs on colon cancer and its mechanism[J]. Journal of International Oncology, 2020, 47(1): 51-55.
[5]	Zhao Gaochuan, Chen Qingqi, Pang Li, Cheng Zheng, Mai Fangqi.Serum levels and clinical significances of miR-205 and miR-221 in patients with colon cancer[J]. Journal of International Oncology, 2019, 46(9): 526-530.
[6]	HUANG Jiang, ZHANG Sheng-Jun, BAI Li-Jie, CHANG Qi.Relationship between the decrease of serum level of carcinoembryonic antigen during perioperative period and the prognosis in patients with colon cancer[J]. Journal of International Oncology, 2017, 44(8): 662-667.
[7]	黄虞，杜冀晖，龚慧，王秀，王磊，李一凡.miR-92a promotes colorectal cancer cell proliferation by regulation of KLF4 gene expression[J]. Journal of International Oncology, 2017, 44(11): 812-818.
[8]	Wan Lijuan, Chen Mingwei.Relationship between insulin resistance related factors and colon cancer stem cells[J]. Journal of International Oncology, 2017, 44(10): 790-793.
[9]	Cui Jing, Tan Hui, Jiang Lei, Yuan Wenzhen, Guan Quanlin.Association between XPC Lys939Gln(A/C) gene polymorphism and the susceptibility of gastric cancer: a Metaanalysis[J]. Journal of International Oncology, 2016, 43(8): 597-602.
[10]	Pan Zhongya, Long Xinghua.Breast cancer metastasis suppressor gene 1 correlates with progression of cancer: a Metaanalysis[J]. Journal of International Oncology, 2016, 43(8): 603-608.
[11]	GAN Ya-Ping, GUO Xiao-Hua, ZHANG Jun-Yu, XU Qing-Qing, WU Jiang, WANG Ren-Yong, QIU Min, JIANG Ru-Gang, LIU Fu-Xing, NING Zhi-Feng.Construction of colonic cancer drugresistant cell line COLO and its relationship with tumor stem cells[J]. Journal of International Oncology, 2016, 43(8): 646-650.
[12]	Wang Jianxun*, Zeng Tian, Zhang Peng, Wang Zhigang, Lei Hailu..Effects of tumor suppressor NDRG2 gene on proliferation and invasive ability of colon cancer cell line SW620[J]. Journal of International Oncology, 2016, 43(6): 401-404.
[13]	Ma Wen, Cai Hongyi, Miao Guoying, Hu Yongguo, Wang Jiankai, Zhang Lijuan.Postoperative radiotherapy and postoperative chemotherapy for patients with endometrial cancer: a Meta-analysis[J]. Journal of International Oncology, 2016, 43(11): 829-834.
[14]	Zhen Ya′nan, Xiao Ruixue, Xu Huirong, Li Jianning, Shi Huiyong, Xu Zhongfa.Meta-analysis of the efficacies of laparoscopic intersphincteric resection and laparotomy for ultra low rectal cancer[J]. Journal of International Oncology, 2016, 43(1): 17-22.
[15]	Guo Hongyan, He Lizhen, Zhang Yunfei, Zhang Hong, Jin Huiqin, An Wenwen.Metastasis-associated in colon cancer 1 and its role in cancer[J]. Journal of International Oncology, 2016, 43(1): 32-35.