Mechanism of anticarcinogenic function of ellagic acid in gastrointestinal cancers

Abstract

Zhao Jinlu, Li Guodong, Liu Ming. Mechanism of anticarcinogenic function of ellagic acid in gastrointestinal cancers[J]. Journal of International Oncology, 2016, 43(6): 472-474.

［1］刘新光. 消化系统恶性肿瘤的临床与研究［J］, 实用医院临床杂志, 2011, 8(1): 1-2. ［2］ Lee KW, Bode AM, Dong Z. Molecular targets of phytochemicals for cancer prevention［J］. Nat Rev Cancer, 2011, 11(3): 211-218. DOI: 10.1038/nrc3017. ［3］ NúezSnchez MA, GarcíaVillalba R, MonederoSaiz T, et al. Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients［J］. 2014, 58(6): 1199-1211. DOI: 10.1002/mnfr.201300931. ［4］ Heber D. Multitargeted therapy of cancer by ellagitannins［J］. Cancer Lett, 2008, 269(2): 262-268. DOI: 10.1016/j. canlet. 2008.03.043. ［5］ Nambiar D, Rajamani P, Singh RP. Effects of phytochemicals on ionization radiationmediated carcinogenesis and cancer therapy［J］. Mutat Res, 2011, 728(3): 139-157. DOI: 10.1016/j.mrrev.2011.07.005. ［6］ Chen HS, Bai MH, Zhang T, et al. Ellagic acid induces cell cycle arrest and apoptosis through TGFβ/Smad3 signaling pathway in human breast cancer MCF7 cells［J］. Int J Oncol, 2015, 46(4): 1730-1738. DOI: 10.3892/ijo.2015.2870. ［7］ Anitha P, Priyadarsini RV, Kavitha K, et al. Ellagic acid coordinately attenuates Wnt/β-catenin and NFκB signaling pathways to induce intrinsic apoptosis in an animal model of oral oncogenesis［J］. Eur J Nutr, 2013, 52(1): 75-84. DOI: 10.1007/s00394-011-0288-y. ［8］ Weisburg JH, Schuck AG, Reiss SE, et al. Ellagic acid, a dietary polyphenol, selectively cytotoxic to HSC-2 oral carcinoma cells［J］. Anticancer Res, 2013, 33(5): 1829-1836. ［9］ Kowshik J, Giri H, Kishore TK, et al. Ellagic acid inhibits VEGF/VEGFR2, PI3K/Akt and MAPK signaling cascades in the hamster cheek pouch carcinogenesis model［J］. Anticancer Agents Med Chem, 2014, 14(9): 1249-1260. ［10］ Reen RK, Nines R, Stoner GD. Modulation of Nnitrosomethylbenzylamine metabolism by black raspberries in the esophagus and liver of Fischer 344 rats［J］. Nutr Cancer, 2006, 54(1): 47-57. DOI: 10.1207/s15327914nc5401_6. ［11］Zhao M, Tang SN, Marsh JL, et al. Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice［J］. Cancer Lett, 2013, 337(2): 210-217. DOI: 10.1016/j.canlet.2013.05.009. ［12］ Edderkaoui M, Lugea A, Hui H, et al. Ellagic acid and embelin affect key cellular components of pancreatic adenocarcinoma, cancer, and stellate cells［J］. Nutr Cancer, 2013, 65(8): 1232-1244. DOI: 10.1080/01635581.2013.832779. ［13］ Srigopalram S, Jayraaj IA, Kaleeswaran B, et al. Ellagic acid normalizes mitochondrial outer membrane permeabilization and attenuates inflammationmediated cell proliferation in experimental liver cancer［J］. Appl Biochem Biotechnol, 2014, 173(8): 2254-2266. DOI: 10.1007/s12010-014-1031-y. ［14］ Umesalma S, Nagendraprabhu P, Sudhandiran G. Ellagic acid inhibits proliferation and induced apoptosis via the Akt signaling pathway in HCT15 colon adenocarcinoma cells［J］. Mol Cell Biochem, 2015, 399(1/2): 303-313. DOI: 10.1007/s11010-014-2257-2. ［15］Umesalma S, Nagendraprabhu P, Sudhandiran G. Antiproliferative and apoptoticinducing potential of ellagic acid against 1,2dimethyl hydrazineinduced colon tumorigenesis in Wistar rats［J］. Mol Cell Biochem, 2014, 388(1/2): 157-172. DOI: 10.1007/s11010-013-1907-0. ［16］Umesalma S, Sudhandiran G. Ellagic acid prevents rat colon carcinogenesis induced by 1, 2 dimethyl hydrazine through inhibition of AKTphosphoinositide3 kinase pathway［J］. Eur J Pharmacol, 2011, 660(2/3): 249-258. DOI: 10.1016/j. ejphar. 2011. 03.036. ［17］Lea MA, Ibeh C, Han L, et al. Inhibition of growth and induction of differentiation markers by polyphenolic molecules and histone deacetylase inhibitors in colon cancer cells［J］. Anticancer Res, 2010, 30(2): 311-318. ［18］Marín M, María Giner R, Ríos JL, et al. Intestinal antiinflammatory activity of ellagic acid in the acute and chronic dextrane sulfate sodium models of mice colitis［J］. J Ethnopharmacol, 2013, 150(3): 925-934. DOI: 10.1016/j.jep.2013.09.030. ［19］NúezSánchez MA, GonzálezSarrías A, RomoVaquero M. Dietary phenolics against colorectal cancer—from promising preclinical results to poor translation into clinical trials: pitfalls and future needs［J］. Mol Nutr Food Res, 2015, 59(7): 1274-1291. DOI: 10.1002/mnfr.201400866. ［20］ GonzálezSarrías A, GiménezBastida JA, NúezSánchez M, et al. PhaseⅡ metabolism limits the antiproliferative activity of urolithins in human colon cancer cells［J］. Eur J Nutr, 2014, 53(3): 853-864. DOI: 10.1007/s00394-013-0589-4. ［21］GonzálezSarrías A, ToméCarneiro J, Bellesia A, et al. The ellagic acidderived gut microbiota metabolite, urolithin A, potentiates the anticancer effects of 5fluorouracil chemotherapy on human colon cancer cells［J］. Food Funct, 2015, 6(5): 1460-1469. DOI: 10.1039/c5fo00120j. ［22］Cho H, Jung H, Lee H, et al. Chemopreventive activity of ellagitannins and their derivatives from black raspberry seeds on HT-29 colon cancer cells［J］. 2015, 6(5): 1675-1683. DOI: 10.1039/c5fo00274e. ［23］Ramírez de Molina A, Vargas T, Molina S, et al. The ellagic acid derivative 4,4′diOmethylellagic acid efficiently inhibits colon cancer cell growth through a mechanism involving WNT16［J］. J Pharmacol Exp Ther, 2015, 353(2): 433-444. DOI: 10.1124/jpet.114.221796.

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Mechanism of anticarcinogenic function of ellagic acid in gastrointestinal cancers

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