%A Wang Wei, Yang Xuejun %T Role of sodium hydrogen exchanger isoform 1 in tumor microenvironment %0 Journal Article %D 2017 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673422X.2017.03.012 %P 205-208 %V 44 %N 3 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_10177.shtml} %8 2017-03-08 %X The reversed pH gradient across the cell membrane on account of intracellular alkalinization and extracellular acidosis is an importart characteristic of tumor microenvironment. Sodium hydrogen exchanger isoform 1 (NHE1) is ubiquitously expressed at the plasma membrane of many types of cells, which plays a critical role in intracellular pH and cell volume homeostasis. NHE1 plays an important role in the regulation of tumor microenvironment and involves in tumor migration and invasion, which may be a potential new target in anticancer therapy.